ZFIN ID: ZDB-GENE-050417-274
Gene Name: NADH:ubiquinone oxidoreductase core subunit S3
Gene Symbol: ndufs3    Nomenclature History

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Previous Name: zgc:112520

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to mitochondrial respiratory chain complex I. Is expressed in male organism. Human ortholog(s) of this gene implicated in mitochondrial complex I deficiency. Orthologous to human NDUFS3 (NADH:ubiquinone oxidoreductase core subunit S3).
Genome Resources: Alliance (1),  Gene:550451 (1),  Ensembl(GRCz11):ENSDARG00000015385 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7148616]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16724 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ndufs3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mitochondrial complex I deficiency, nuclear type 8 618230
    DISEASE ASSOCIATED WITH ndufs3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component mitochondrial respiratory chain complex I (more)
    Molecular Function NADH dehydrogenase (ubiquinone) activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ndufs3-201 (1)    Ensembl 916
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB1-ndufs3 monoclonal IgG1 , k Mouse WB MitoSciences
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ndufs3 No data available
    MARKER RELATIONSHIPS
    ndufs3 Contained in: [BAC] CH211-274E20 (1)
    ndufs3 Encodes: [EST] IMAGE:7148616 (1)
    [cDNA] MGC:112520 (1), MGC:192538 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001017755 (1) 909 nt
    Genomic GenBank:CR318601 (1) 165501 nt
    Select Tool
    Polypeptide UniProtKB:F1R4C8 (1) 255 aa
    Sequence Information (all 14)
    ORTHOLOGY for ndufs3 ( Chr: 7 )
    CITATIONS (26)