ZFIN ID: ZDB-GENE-050417-26
Gene Name: carbonic anhydrase VIII
Gene Symbol: ca8
Sequence Ontology ID : SO:0000704

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Attributions

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Previous Names: CARP VIII (1), zgc:110118 (1)

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(Including Attributions)
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have carbonate dehydratase activity and zinc ion binding activity; involved in cerebellum development, chordate embryonic development, and swimming behavior; used to study cerebellar  ...
GENE EXPRESSION
All Expression Data: 16 figures from 6 publications
Directly Submitted Expression Data: 7 figures (19 images) from Thisse et al., 2004 [MGC:110118]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8898 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 5 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH ca8 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cerebellar ataxia, mental retardation and dysequlibrium syndrome Cerebellar ataxia and mental retardation with or without quadrupedal locomotion 3 613227
    DISEASE ASSOCIATED WITH ca8 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    cerebellar ataxia, mental retardation and dysequlibrium syndrome AB + MO3-ca8 standard conditions Huang et al., 2014
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cerebellum development (more)
    Cellular Component cellular_component (more)
    Molecular Function carbonate dehydratase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001148 (1)
  • InterPro:IPR018338 (1)
  • InterPro:IPR023561 (1)
  • InterPro:IPR036398 (1)
  • PROSITE:PS00162 (1)
  • PROSITE:PS51144 (1)
  • Pfam:PF00194 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ca8-001 (1) 2174
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ca8
    MARKER RELATIONSHIPS
    ca8Contained in: [BAC] DKEY-59O6 (1) (order this)
    ca8Encodes: [cDNA] MGC:110118 (1) (order this), MGC:191811 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001017571 (1) 2234bp
    Genomic GenBank:CR847864 (1) 81867bp
    Select Tool
    Polypeptide UniProtKB:B0V1F9 (1) 281aa
    Sequence Clusters UniGene:13836 (1)
    Sequence Information (all 15)
    OTHER ca8 GENE PAGES
  • Alliance (1)
  • Gene:550233 (1)
  • VEGA:OTTDARG00000021499 (1)
  • Ensembl(GRCz11):ENSDARG00000039098 (2)
  • ORTHOLOGY for ca8 (Chr: 2)
    CITATIONS (29)