ZFIN ID: ZDB-GENE-050407-3
Gene Name: paired like homeobox 2Bb
Gene Symbol: phox2bb    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in enteric nervous system development and sympathetic ganglion development. Predicted to localize to nucleus. Is expressed in digestive system; nervous system; and presumptive enteric nervous system. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human PHOX2B (paired like homeobox 2B).
Genome Resources: Alliance (1),  Gene:544654 (1),  Ensembl(GRCz11):ENSDARG00000091029 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-phox2bb N/A 2
MO2-phox2bb N/A 1
MO3-phox2bb N/A 1
MO4-phox2bb N/A 1
DISEASE ASSOCIATED WITH phox2bb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital central hypoventilation syndrome Alliance Central hypoventilation syndrome, congenital, with or without Hirschsprung disease 209880
Neuroblastoma with Hirschsprung disease 613013
{Neuroblastoma, susceptibility to, 2} 613013
DISEASE ASSOCIATED WITH phox2bb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process sympathetic ganglion development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA phox2bb-202 (1)    Ensembl 2197
phox2bb-203 (1)    Ensembl 1004
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-phox2bb polyclonal Rabbit IHC 2
Ab2-phox2bb polyclonal Guinea pig 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM phox2bb
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-8.3phox2bb:Kaede) phox2bb Kaede Danio rerio 1 6
Tg(phox2bb:EGFP) phox2bb EGFP Danio rerio 13 2
Tg(phox2bb:GAL4-VP16,myl7:Cerulean) myl7phox2bb CeruleanGAL4VP16 Danio rerio 1 4
Tg2(phox2bb:EGFP) phox2bb EGFP Danio rerio 1 18
MARKER RELATIONSHIPS
phox2bb Contained in: [BAC] CH73-77D24 (1), DKEYP-50C7 (1)
phox2bb Encodes: [cDNA] MGC:194287 (1), MGC:194293 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001014818 (1) 2164 nt
Genomic GenBank:CT963086 (1) 84517 nt
Select Tool
Polypeptide UniProtKB:Q3T498 (1) 285 aa
Sequence Information (all 20)
ORTHOLOGY for phox2bb ( Chr: 14 )
CITATIONS (61)