ZFIN ID: ZDB-GENE-050407-3
Gene Name: paired like homeobox 2Bb
Gene Symbol: phox2bb
Sequence Ontology ID : SO:0000704

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have sequence-specific DNA binding activity; involved in enteric nervous system development and sympathetic ganglion development; predicted to localize to the nucleus; orthologous to  ...
GENE EXPRESSION
All Expression Data: 55 figures from 29 publications
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents:
PHENOTYPE
Data: 5 figures from 2 publications
Observed in:
DISEASE ASSOCIATED WITH phox2bb HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
congenital central hypoventilation syndrome Central hypoventilation syndrome, congenital, with or without Hirschsprung disease 209880
Neuroblastoma with Hirschsprung disease 613013
{Neuroblastoma, susceptibility to, 2} 613013
DISEASE ASSOCIATED WITH phox2bb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process sympathetic ganglion development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000061728 (1) 2197
    phox2bb-002 (1) 1004
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM phox2bb
    MARKER RELATIONSHIPS
    phox2bbContained in: [BAC] CH73-77D24 (1) (order this), DKEYP-50C7 (1)
    phox2bbEncodes: [cDNA] MGC:194287 (1) (order this), MGC:194293 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001014818 (1) 2164bp
    Genomic GenBank:CT963086 (1) 84517bp
    Select Tool
    Polypeptide UniProtKB:Q3T498 (1) 285aa
    Sequence Clusters UniGene:160837 (1)
    Sequence Information (all 22)
    OTHER phox2bb GENE PAGES
  • Alliance (1)
  • Gene:544654 (1)
  • VEGA:OTTDARG00000042726 (1)
  • Ensembl(GRCz11):ENSDARG00000091029 (1)
  • ORTHOLOGY for phox2bb (Chr: 14)
    CITATIONS (58)