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ZIRC
ZFIN ID: ZDB-GENE-050327-73
Gene Name: VPS33B late endosome and lysosome associated
Gene Symbol: vps33b    Nomenclature History

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Previous Name: zgc:110803

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Involved in intrahepatic bile duct development. Predicted to localize to the late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in arthrogryposis, renal dysfunction, and cholestasis 1; cholestasis; and kidney disease. Is expressed in gut; liver; and pancreas. Orthologous to human VPS33B (VPS33B late endosome and lysosome associated).
Genome Resources: Alliance (1),  Gene:541534 (1),  Ensembl(GRCz11):ENSDARG00000044813 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Matthews et al., 2005
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9761 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12663 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27045 Point Mutation Unknown Splice Site ENU
    sa31593 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34177 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-vps33b N/A 2
    MO2-vps33b N/A 2
    MO3-vps33b N/A 2
    DISEASE ASSOCIATED WITH vps33b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    arthrogryposis, renal dysfunction, and cholestasis 1 Alliance Arthrogryposis, renal dysfunction, and cholestasis 1 208085
    DISEASE ASSOCIATED WITH vps33b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intrahepatic bile duct development (more)
    Cellular Component endosome (more)
    Molecular Function molecular_function (more)
    GO Terms (all 11)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vps33b-201 (1)    Ensembl 2634
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vps33b No data available
    MARKER RELATIONSHIPS
    vps33b Contained in: [BAC] DKEY-25J19 (1) (order this)
    vps33b Encodes: [cDNA] MGC:110803 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001014348 (1) 2665 bp
    Genomic GenBank:CR382298 (1) 244811 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QIC2 (1) 617 aa
    Sequence Clusters UniGene:78295 (1)
    Sequence Information (all 13)
    ORTHOLOGY for vps33b ( Chr: 7 )
    CITATIONS (20)