Gene
zdhhc2
- ID
- ZDB-GENE-050320-58
- Name
- zDHHC palmitoyltransferase 2
- Symbol
- zdhhc2 Nomenclature History
- Previous Names
-
- wu:fk53a02
- zgc:110777 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including peptidyl-L-cysteine S-palmitoylation; synapse assembly; and synaptic vesicle maturation. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; postsynaptic density; and postsynaptic recycling endosome. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110777 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa42405 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Palmitoyltransferase, DHHC domain | Palmitoyltransferase PFA4/ZDHHC16/ZDHHC20/ERF2-like |
|---|---|---|---|---|
| UniProtKB:A0A8M9QKK4 | InterPro | 374 | ||
| UniProtKB:Q5BLG4 | InterPro | 361 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
zdhhc2-203
(1)
|
Ensembl | 514 nt | ||
| mRNA |
zdhhc2-201
(1)
|
Ensembl | 2,610 nt | ||
| ncRNA |
zdhhc2-003
(1)
|
Ensembl | 775 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-186K13 | ZFIN Curated Data | |
| Encodes | EST | fk53a02 | ||
| Encodes | cDNA | MGC:110777 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191984 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013492 (1) | 2530 nt | ||
| Genomic | GenBank:BX530719 (1) | 197865 nt | ||
| Polypeptide | UniProtKB:A0A8M9QKK4 (1) | 374 aa |
- Du, Z., Chen, X., Li, X., He, K., Ji, S., Shi, W., Hao, A. (2016) Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Biochemical and Biophysical Research Communications. 475(2):194-201
- Wang, C., Chen, X., Shi, W., Wang, F., Du, Z., Li, X., Yao, Y., Liu, T., Shao, T., Li, G., Hao, A. (2015) 2-bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Neurotoxicology and teratology. 50:53-63
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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