ZFIN ID: ZDB-GENE-050320-36
Gene Name: transcriptional and immune response regulator a
Gene Symbol: tcima    Nomenclature History

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Previous Names: tc1a (1), fa99h09, wu:fa99h09, zgc:110340

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have Notch binding activity. Predicted to be involved in endothelial cell activation involved in immune response and negative regulation of Notch signaling pathway. Predicted to localize to cytosol and nucleus. Is expressed in several structures, including cardiovascular system; endothelial cell; epidermis; peripheral olfactory organ; and pharyngeal arch. Orthologous to human TCIM (transcriptional and immune response regulator).
Genome Resources: Alliance (1),  Gene:541345 (1),  Ensembl(GRCz11):ENSDARG00000079497 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [MGC:110340]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20427 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tcima HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tcima VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endothelial cell activation involved in immune response (more)
    Cellular Component cytosol (more)
    Molecular Function Notch binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tcima-201 (1)    Ensembl 1009
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tcima No data available
    MARKER RELATIONSHIPS
    tcima Contained in: [BAC] CH211-133N22 (1)
    tcima Encodes: [EST] fa99h09
    [cDNA] MGC:110340 (1), MGC:191612 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001013472 (1)
    Genomic GenBank:BX666060 (1) 180348 nt
    Select Tool
    Polypeptide UniProtKB:Q5BJJ4 (1) 100 aa
    Sequence Information (all 14)
    ORTHOLOGY for tcima ( Chr: 5 )
    CITATIONS (16)