Gene

prdx1

ID
ZDB-GENE-050320-35
Name
peroxiredoxin 1
Symbol
prdx1 Nomenclature History
Previous Names
  • hm:zehl0637
  • zgc:110343 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have thioredoxin peroxidase activity. Involved in leukocyte activation. Localizes to protein-containing complex. Is expressed in several structures, including diencephalon; digestive system; epidermis; lateral line; and neural crest. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prdx1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
methylmalonic aciduria and homocystinuria type cblC Alliance Methylmalonic aciduria and homocystinuria, cblC type, digenic 277400
Associated With prdx1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Domain IPR013766 Thioredoxin domain
Domain IPR019479 Peroxiredoxin, C-terminal
Family IPR024706 Peroxiredoxin, AhpC-type
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Domain Details Per Protein
Protein Length Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant Peroxiredoxin, AhpC-type Peroxiredoxin, C-terminal Thioredoxin domain Thioredoxin-like superfamily
UniProtKB:A7MCD6 201
UniProtKB:A2AWE1 199
UniProtKB:Q5BJJ3 199
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
AB1-prdx1 polyclonal Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations