ZFIN ID: ZDB-GENE-050309-206
Gene Name: protein kinase, interferon-inducible double stranded RNA dependent activator
Gene Symbol: prkra    Nomenclature History

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Previous Names: im:7151758, zgc:162619 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have double-stranded RNA binding activity; enzyme activator activity; and kinase activity. Predicted to be involved in production of siRNA involved in RNA interference. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in dystonia 16. Orthologous to human PRKRA (protein activator of interferon induced protein kinase EIF2AK2).
Genome Resources: Alliance (1),  Gene:557370 (1),  Ensembl(GRCz11):ENSDARG00000076718 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7151758]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41332 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH prkra HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dystonia 16 Alliance Dystonia 16 612067
    DISEASE ASSOCIATED WITH prkra VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process production of siRNA involved in RNA interference (more)
    Cellular Component cytoplasm (more)
    Molecular Function double-stranded RNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR007110 Immunoglobulin-like domain
    Domain IPR014720 Double-stranded RNA-binding domain
    Domain IPR032478 Staufen, C-terminal
    Family IPR033363 Interferon-inducible double-stranded RNA-dependent protein kinase activator A
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prkra-201 (1)    Ensembl 1596
    prkra-202 (1)    Ensembl 934
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prkra No data available
    MARKER RELATIONSHIPS
    prkra Contained in: [BAC] CH73-57B20 (1), CH73-108H4 (1)
    prkra Encodes: [EST] IMAGE:7151758 (1)
    [cDNA] MGC:162619 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001089361 (1) 1600 bp
    Genomic GenBank:FP102120 (1) 82853 bp
    Select Tool
    Polypeptide UniProtKB:F1Q8C8 (1) 289 aa
    Sequence Information (all 18)
    ORTHOLOGY for prkra ( Chr: 9 )
    CITATIONS (25)