ZFIN ID: ZDB-GENE-050307-1
Gene Name: kinesin family member 7
Gene Symbol: kif7    Nomenclature History

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Previous Names: cos2 (1), costal2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have ATPase activity; microtubule binding activity; and microtubule motor activity. Involved in determination of left/right symmetry; negative regulation of smoothened signaling pathway; and photoreceptor cell outer segment organization. Localizes to Hedgehog signaling complex; cilium; and cytoplasm. Is expressed in myotome; neural tube; otic vesicle; and somite. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Orthologous to human KIF7 (kinesin family member 7).
Genome Resources: Alliance (1),  Gene:544651 (1),  Ensembl(GRCz11):ENSDARG00000033099 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
i271 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
i272 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
i273 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
la011167Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • mw406 Complex Unknown Premature Stop CRISPR
    sa8588 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16261 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20875 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34018 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38596 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kif7 1
    CRISPR2-kif7 1
    MO1-kif7 N/A 4
    MO2-kif7 N/A 1
    DISEASE ASSOCIATED WITH kif7 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acrocallosal syndrome Alliance Acrocallosal syndrome 200990
    Joubert syndrome 12 200990
    hydrolethalus syndrome 2 Alliance ?Hydrolethalus syndrome 2 614120
    ?Al-Gazali-Bakalinova syndrome 607131
    DISEASE ASSOCIATED WITH kif7 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component cilium (more)
    Molecular Function protein binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kif7-201 (1)    Ensembl 5802
    ncRNA kif7-002 (1) 588
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-kif7 polyclonal Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kif7 No data available
    MARKER RELATIONSHIPS
    kif7 Contained in: [BAC] CH73-366C23 (1), CH211-132D3 (1), DKEY-234G11 (1) (order this), DKEY-265M8 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014816 (1) 4092 nt
    Genomic GenBank:CU467822 (1) 185620 nt
    Select Tool
    Polypeptide UniProtKB:F1QH25 (1) 1363 aa
    Sequence Information (all 14)
    ORTHOLOGY for kif7 ( Chr: 7 )
    CITATIONS (34)