ZFIN ID: ZDB-GENE-050302-113
Gene Name: neuregulin 1
Gene Symbol: nrg1
Sequence Ontology ID : SO:0000704

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Previous Name: wu:fm70e01

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(Including Attributions)
Location: Chr: 10 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have signaling receptor binding activity; involved in several processes, including animal organ development, fin regeneration, and nervous system development; predicted to localize to  ...
GENE EXPRESSION
All Expression Data: 17 figures from 12 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns101 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
la017618Tg Transgenic Insertion Unknown Unknown DNA
la027207Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • nc28 Insertion Exon 3 Frameshift, Premature Stop CRISPR
    nc29 Small Deletion Exon 3 Frameshift, Premature Stop CRISPR
    nc26 Small Deletion Exon 6 Frameshift, Premature Stop CRISPR
    nc27 Small Deletion Exon 6 Frameshift, Premature Stop CRISPR
    sa45389 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • z26 Point Mutation Unknown Unknown
    Targeting reagents:
    PHENOTYPE
    Data: 21 figures from 9 publications
    Observed in:
    DISEASE ASSOCIATED WITH nrg1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    schizophrenia 6 {?Schizophrenia, susceptibility to} 603013
    DISEASE ASSOCIATED WITH nrg1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neural crest cell migration (more)
    Cellular Component integral component of membrane (more)
    Molecular Function signaling receptor binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000742 (1)
  • InterPro:IPR002154 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR018250 (1)
  • InterPro:IPR036179 (1)
  • InterPro:IPR040180 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF02158 (1)
  • Pfam:PF07679 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nrg1-001 (1) 2991
    ncRNA nrg1-002 (1) 511
    mRNA nrg1-003 (1) 2193
    nrg1-004 (1) 2645
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nrg1
    MARKER RELATIONSHIPS
    nrg1Contained in: [BAC] CH73-386K7 (1) (order this), DKEY-237I12 (1) (order this), DKEYP-45E9 (1), DKEYP-73E12 (1)
    nrg1Encodes: [EST] fm70e01
    [cDNA] MGC:195082 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044911 (1) 2653bp
    Genomic GenBank:BX537303 (1) 204522bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IBM0 (1) 730aa
    Sequence Clusters UniGene:133124 (1)
    Sequence Information (all 66)
    OTHER nrg1 GENE PAGES
  • Alliance (1)
  • Gene:796461 (1)
  • VEGA:OTTDARG00000019703 (1)
  • Ensembl(GRCz11):ENSDARG00000104314 (1)
  • ORTHOLOGY for nrg1 (Chr: 10)
    CITATIONS (53)