ZFIN ID: ZDB-GENE-050227-1
Gene Name: F-box and leucine-rich repeat protein 22
Gene Symbol: fbxl22    Nomenclature History

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Previous Name: zgc:110743

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and regulation of cardiac muscle cell contraction. Predicted to colocalize with mitochondrial respiratory chain complex I. Orthologous to human FBXL22 (F-box and leucine rich repeat protein 22).
Genome Resources: Alliance (1),  Gene:503591 (1),  Ensembl(GRCz11):ENSDARG00000096995 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa44314 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fbxl22 N/A 1
    MO2-fbxl22 N/A 1
    DISEASE ASSOCIATED WITH fbxl22 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fbxl22 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of cardiac muscle cell contraction (more)
    Cellular Component SCF ubiquitin ligase complex (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fbxl22-201 (1)    Ensembl 1208
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fbxl22 No data available
    MARKER RELATIONSHIPS
    fbxl22 Contained in: [BAC] DKEYP-73B11
    fbxl22 Encodes: [cDNA] MGC:110743 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001013279 (1) 1100 nt
    Genomic GenBank:CR391977 (1) 189510 nt
    Select Tool
    Polypeptide UniProtKB:F1R1F0 (1) 227 aa
    Sequence Information (all 9)
    ORTHOLOGY for fbxl22 ( Chr: 25 )
    CITATIONS (14)