ZFIN ID: ZDB-GENE-050208-620
Gene Name: asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
Gene Symbol: aspm
Previous Names: fc13b04, si:dkey-114d20.4, wu:fc13b04
Location: Chr: 22   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  brain, central nervous system, ciliary marginal zone, eye (all 16) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: aspmsa1008/sa1008(Tupfel long fin)
Knockdown reagents: MO1-aspm (1), MO2-aspm (1)

Allele Type Mutagen Suppliers
la014203Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1008 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11648 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12763 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13529 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa17838 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa24170 Point Mutation ENU
    sa24171 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa24172 Point Mutation ENU
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in: apoptotic process, eye, head, mitotic nuclear division (all 7) expand

    Phenotype of Human Orthologue OMIM Phenotype ID
    Microcephaly 5, primary, autosomal recessive 608716
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitotic cell cycle (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000048 (1)
  • InterPro:IPR001715 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR022613 (1)
  • InterPro:IPR027401 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR029955 (1)
  • PROSITE:PS50021 (1)
  • PROSITE:PS50096 (1)
  • Pfam:PF00612 (1)
  • Pfam:PF11971 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA aspm-001 (1) 10507
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aspm No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    aspm Contained in: [BAC] DKEY-114D20 (1) (order this)
    aspm Encodes: [EST] fc13b04
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001123373 (1) 10507 bp
    Genomic GenBank:CR388178 (1) 171742 bp
    Select Tool
    Polypeptide UniProtKB:F1R6K8 (1) 3411 aa
    Sequence Clusters UniGene:156013 (1)
    Sequence Information (all 57)
    OTHER aspm GENE PAGES
  • Gene:554173 (1)
  • VEGA:OTTDARG00000011999 (1)
  • Ensembl(Zv9):ENSDARG00000071442 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish aspm 22  
    Human ASPM 1 (1q31)
  • OMIM:605481
  • Gene:259266
  • Mouse Aspm 1 ( 61.45 cM)
  • MGI:1334448
  • Gene:12316
  • Orthology Details
    CITATIONS (21)