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ZIRC
ZFIN ID: ZDB-GENE-050208-620
Gene Name: abnormal spindle microtubule assembly
Gene Symbol: aspm    Nomenclature History

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Previous Names: fc13b04, si:dkey-114d20.4, wu:fc13b04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Involved in mitotic cell cycle. Used to study microcephaly. Human ortholog(s) of this gene implicated in microcephaly; primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 5; and visual epilepsy. Is expressed in digestive system; nervous system; optic cup; otic vesicle; and pectoral fin bud. Orthologous to human ASPM (abnormal spindle microtubule assembly).
Genome Resources: Alliance (1),  Gene:554173 (1),  Ensembl(GRCz11):ENSDARG00000103754 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014203Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa447 Point Mutation Unknown Splice Site ENU
    sa1008 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa5003 Point Mutation Unknown Splice Site ENU
    sa6712 Point Mutation Unknown Premature Stop ENU
    sa9075 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11648 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12763 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13529 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17838 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24169 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24170 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24171 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24172 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37516 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37517 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37518 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43847 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43848 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43849 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-aspm N/A 1
    MO2-aspm N/A 1
    DISEASE ASSOCIATED WITH aspm HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary autosomal recessive microcephaly 5 Alliance Microcephaly 5, primary, autosomal recessive 608716
    DISEASE ASSOCIATED WITH aspm VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    microcephaly WT + MO2-aspm standard conditions Novorol et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitotic cell cycle (more)
    GO Terms (all 2)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aspm-201 (1)    Ensembl 10507
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aspm No data available
    MARKER RELATIONSHIPS
    aspm Contained in: [BAC] DKEY-114D20 (1) (order this)
    aspm Encodes: [EST] fc13b04
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001123373 (1) 10507 bp
    Genomic GenBank:CR388178 (1) 171742 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4INR1 (1) 3391 aa
    Sequence Clusters UniGene:156013 (1)
    Sequence Information (all 57)
    ORTHOLOGY for aspm ( Chr: 22 )
    CITATIONS (25)