ZFIN ID: ZDB-GENE-050208-620
Gene Name: abnormal spindle microtubule assembly
Gene Symbol: aspm

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Previous Names: fc13b04, si:dkey-114d20.4, wu:fc13b04

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(Including Attributions)
Location: Chr: 22 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  brain, central nervous system, ciliary marginal zone, eye (all 16) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014203Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa447 Point Mutation Unknown Splice Site ENU
    sa1008 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa5003 Point Mutation Unknown Splice Site ENU
    sa6712 Point Mutation Unknown Premature Stop ENU
    sa9075 Point Mutation Unknown Premature Stop ENU
    sa11648 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12763 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13529 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17838 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24169 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24170 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24171 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa24172 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37516 Point Mutation Unknown Premature Stop ENU
    sa37517 Point Mutation Unknown Premature Stop ENU
    sa37518 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43847 Point Mutation Unknown Premature Stop ENU
    sa43848 Point Mutation Unknown Premature Stop ENU
    sa43849 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-aspm (1), MO2-aspm (1)
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in: apoptotic process, eye, head, mitotic nuclear division (all 7) expand
    DISEASE ASSOCIATED WITH aspm HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    microcephaly Microcephaly 5, primary, autosomal recessive 608716
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitotic cell cycle (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000048 (1)
  • InterPro:IPR001715 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR027401 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR029955 (1)
  • InterPro:IPR031549 (1)
  • PROSITE:PS50021 (1)
  • PROSITE:PS50096 (1)
  • Pfam:PF00307 (1)
  • Pfam:PF00612 (1)
  • Pfam:PF15780 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA aspm-001 (1) 10507
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM aspm No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    aspmContained in: [BAC] DKEY-114D20 (1) (order this)
    aspmEncodes: [EST] fc13b04
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001123373 (1) 10507bp
    Genomic GenBank:CR388178 (1) 171742bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IVG8 (1) 3411aa
    Sequence Clusters UniGene:156013 (1)
    Sequence Information (all 58)
    OTHER aspm GENE PAGES
  • Gene:554173 (1)
  • VEGA:OTTDARG00000011999 (1)
  • Ensembl(GRCz10):ENSDARG00000103754 (1)
  • ORTHOLOGY for aspm (Chr: 22)
    Species Symbol Chromosome Accession # Evidence
    Human ASPM 1
  • Gene:259266
  • OMIM:605481
  • HGNC:19048
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Mouse Aspm 1
  • MGI:1334448
  • Gene:12316
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (21)