Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-050208-620
Gene Name: asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
Gene Symbol: aspm
Previous Names: fc13b04, si:dkey-114d20.4, wu:fc13b04
Location: Chr: 22   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  brain, central nervous system, ciliary marginal zone, eye (all 16) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 1 genotype
Alleles: la014203Tg, sa1008, sa11648, sa12763, sa13529 (all 9) expand
Knockdown reagents: MO1-aspm (1), MO2-aspm (1)
PHENOTYPE
Data: 4 figures from 2 publications
Observed in: apoptotic process, eye, head, mitotic nuclear division (all 7) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Microcephaly 5, primary, autosomal recessive 608716
GENE ONTOLOGY
Ontology GO Term
Biological Process mitotic cell cycle (more)
GO Terms (all 1)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000048 (1)
  • InterPro:IPR001715 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR022613 (1)
  • InterPro:IPR027401 (1)
  • InterPro:IPR027417 (1)
  • PROSITE:PS50021 (1)
  • PROSITE:PS50096 (1)
  • Pfam:PF00612 (1)
  • Pfam:PF11971 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA aspm-001 (1) 10507
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM aspm No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    aspm Contained in: [BAC] DKEY-114D20 (1)
    aspm Encodes: [EST] fc13b04
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001123373 (1) 10507 bp
    Genomic GenBank:CR388178 (1) 171742 bp
    Select Tool
    Polypeptide UniProtKB:F1R6K8 (1) 3411 aa
    Sequence Clusters UniGene:75178 (1)
    Sequence Information (all 57)
    OTHER aspm GENE PAGES
  • Gene:554173 (1)
  • VEGA:OTTDARG00000011999 (1)
  • Ensembl(Zv9):ENSDARG00000071442 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish aspm 22  
    Human ASPM 1 (1q31)
  • OMIM:605481
  • Gene:259266
  • Mouse Aspm 1 ( 61.45 cM)
  • MGI:1334448
  • Gene:12316
  • Orthology Details
    CITATIONS (20)