ZFIN ID: ZDB-GENE-050208-620
Gene Name: abnormal spindle microtubule assembly
Gene Symbol: aspm
Previous Names: fc13b04, si:dkey-114d20.4, wu:fc13b04
Location: Chr: 22 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  brain, central nervous system, ciliary marginal zone, eye (all 16) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
la014203Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1008 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11648 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12763 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13529 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17838 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa24170 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24171 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa24172 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-aspm (1), MO2-aspm (1)
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in: apoptotic process, eye, head, mitotic nuclear division (all 7) expand
    DISEASE ASSOCIATED WITH aspm HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    microcephaly Microcephaly 5, primary, autosomal recessive 608716
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process mitotic cell cycle (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000048 (1)
  • InterPro:IPR001715 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR027401 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR029955 (1)
  • InterPro:IPR031549 (1)
  • PROSITE:PS50021 (1)
  • PROSITE:PS50096 (1)
  • Pfam:PF00307 (1)
  • Pfam:PF00612 (1)
  • Pfam:PF15780 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA aspm-001 (1) 10507
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aspm No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    aspmContained in: [BAC] DKEY-114D20 (1) (order this)
    aspmEncodes: [EST] fc13b04
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001123373 (1) 10507bp
    Genomic GenBank:CR388178 (1) 171742bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IVG8 (1) 3411aa
    Sequence Clusters UniGene:156013 (1)
    Sequence Information (all 58)
    OTHER aspm GENE PAGES 
  • Gene:554173 (1)
  • VEGA:OTTDARG00000011999 (1)
  • Ensembl(GRCz10):ENSDARG00000103754 (1)
  • ORTHOLOGY for aspm (Chr: 22) 
    Species Symbol Chromosome Accession # Evidence
    Human ASPM 1
  • Gene:259266
  • OMIM:605481
  • HGNC:19048
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Mouse Aspm 1
  • MGI:1334448
  • Gene:12316
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (21)