ZFIN ID: ZDB-GENE-050208-475
Gene Name: laminin, alpha 3
Gene Symbol: lama3    Nomenclature History

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Previous Name: si:dkey-121a11.10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have signaling receptor binding activity. Predicted to be involved in several processes, including determination of heart left/right asymmetry; embryonic morphogenesis; and left/right pattern formation. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa; junctional epidermolysis bullosa Herlitz type; junctional epidermolysis bullosa non-Herlitz type; and lung small cell carcinoma. Is expressed in central nervous system; eye; integument; and pectoral fin. Orthologous to human LAMA3 (laminin subunit alpha 3).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000071462 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa5969 Point Mutation Unknown Premature Stop ENU
sa11864 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15223 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24129 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24130 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31071 Point Mutation Unknown Splice Site, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37475 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37476 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37477 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37478 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37479 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43802 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43803 Point Mutation Unknown Splice Site, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lama3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    junctional epidermolysis bullosa Herlitz type Alliance Epidermolysis bullosa, junctional, Herlitz type 226700
    junctional epidermolysis bullosa non-Herlitz type Alliance Epidermolysis bullosa, generalized atrophic benign 226650
    Laryngoonychocutaneous syndrome 245660
    DISEASE ASSOCIATED WITH lama3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion (more)
    Cellular Component integral component of membrane (more)
    Molecular Function signaling receptor binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001791 Laminin G domain
    Domain IPR002049 Laminin EGF domain
    Domain IPR009254 Laminin alpha, domain I
    Domain IPR010307 Laminin domain II
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lama3-201 (1)    Ensembl 3792
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lama3 No data available
    MARKER RELATIONSHIPS
    lama3 Contained in: [BAC] DKEY-121A11 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    Genomic GenBank:BX465190 (1) 183103 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q7H6 (1) 1711 aa
    Sequence Information (all 4)
    ORTHOLOGY for lama3 ( Chr: 22 )
    CITATIONS (17)