ZFIN ID: ZDB-GENE-050208-439
Gene Name: CREB binding protein a
Gene Symbol: crebbpa    Nomenclature History

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Previous Names: CBP-B (1), crebbp, CREBBPb (1), si:dkey-206l1.6, si:dkey-44g23.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Involved in hematopoietic progenitor cell differentiation. Localizes to cytoplasm and nucleus. Is expressed in several structures, including blastoderm; blastodisc; digestive system; segmental plate; and solid lens vesicle. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein).
Genome Resources: Alliance (1),  Gene:566841 (1),  Ensembl(GRCz11):ENSDARG00000104609 (1)
PHENOTYPE
Data: Fig. S2 from Batut et al., 2015
Observed in:
DISEASE ASSOCIATED WITH crebbpa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Rubinstein-Taybi syndrome Alliance Rubinstein-Taybi syndrome 1 180849
Menke-Hennekam syndrome 1 618332
DISEASE ASSOCIATED WITH crebbpa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process hematopoietic progenitor cell differentiation (more)
Cellular Component cytoplasm (more)
Molecular Function histone acetyltransferase activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA crebbpa-201 (1)    Ensembl 8544
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab3-crebbpa polyclonal Rabbit IHC, WB 1
Ab2-crebbpa polyclonal Rabbit IHC, WB 1
Ab1-crebbp polyclonal IgG Rabbit IHC Santa Cruz Biotechnology, Inc.
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM crebbpa No data available
MARKER RELATIONSHIPS
crebbpa Contained in: [BAC] CH211-42G15 (1), DKEY-44G23 (1) (order this), DKEY-101P20 (1) (order this), DKEY-206L1 (1) (order this)
crebbpa Encodes: [EST] dq017641 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005161769 (1) 9155 nt
Genomic GenBank:AL953841 (1) 219929 nt Blast at MegaBLAST
Polypeptide UniProtKB:A0A0R4IPF2 (1) 2349 aa
Sequence Information (all 35)
ORTHOLOGY for crebbpa ( Chr: 22 )
CITATIONS (36)