ZFIN ID: ZDB-GENE-050208-29
Gene Name: lysyl oxidase-like 2b
Gene Symbol: loxl2b    Nomenclature History

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Previous Names: im:7136137, si:dkeyp-32b1.1, wu:fk12g04, zgc:158414

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity; copper ion binding activity; and protein-lysine 6-oxidase activity. Predicted to be involved in several processes, including collagen fibril organization; peptidyl-lysine oxidation; and positive regulation of cell differentiation. Predicted to localize to several cellular components, including basement membrane; chromatin; and endoplasmic reticulum. Is expressed in diencephalon; head mesenchyme; hindbrain; notochord; and pectoral fin. Orthologous to human LOXL2 (lysyl oxidase like 2).
Genome Resources: Alliance (1),  Gene:791144 (1),  Ensembl(GRCz11):ENSDARG00000044074 (2)
GENE EXPRESSION
All Expression Data: 17 figures from 4 publications
Directly Submitted Expression Data: 6 figures (7 images) from Thisse et al., 2004 [IMAGE:7136137]
  6 figures (10 images) from Thisse et al., 2004 [IMAGE:7156383]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14825 Point Mutation Unknown Premature Stop ENU
sa20426 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-loxl2b N/A 2
    PHENOTYPE
    Data: Fig. 5 from Gansner et al., 2007
    Observed in:
    DISEASE ASSOCIATED WITH loxl2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH loxl2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process collagen fibril organization (more)
    Cellular Component basement membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA loxl2b-202 (1)    Ensembl 3555
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM loxl2b No data available
    MARKER RELATIONSHIPS
    loxl2b Contained in: [BAC] CH73-202K21 (1), DKEYP-32B1 (1), DKEYP-38H2 (1)
    loxl2b Encodes: [EST] fk12g04 (1), IMAGE:7136137 (1), IMAGE:7156383 (1)
    [cDNA] MGC:158414 (1), MGC:174590 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080626 (1) 2950 nt
    Genomic GenBank:BX323062 (1) 199133 nt
    Select Tool
    Polypeptide UniProtKB:A1L1V4 (1) 762 aa
    Sequence Information (all 24)
    ORTHOLOGY for loxl2b ( Chr: 5 )
    CITATIONS (29)