ZFIN ID: ZDB-GENE-050126-1
Gene Name: YES proto-oncogene 1, Src family tyrosine kinase
Gene Symbol: yes1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits protein tyrosine kinase activity. Involved in several processes, including adherens junction maintenance; convergent extension involved in gastrulation; and protein autophosphorylation. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase).
Genome Resources: Alliance (1),  Gene:407620 (1), 
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010373Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-yes1 N/A 7
    MO2-yes1 N/A 1
    PHENOTYPE
    Data: Fig. 2 from Sempou et al., 2016
    Observed in:
    DISEASE ASSOCIATED WITH yes1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH yes1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein autophosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein tyrosine kinase activity (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA yes1-201 (1)    Ensembl 4485
    ncRNA yes1-002 (1)    Ensembl 328
    yes1-003 (1)    Ensembl 394
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM yes1 No data available
    MARKER RELATIONSHIPS
    yes1 Contained in: [BAC] CH211-212M21 (1)
    yes1 Encodes: [cDNA] MGC:152910 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001013270 (1) 4550 nt
    Genomic GenBank:BX927088 (1) 201361 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A1A5H8 (1) 546 aa
    Sequence Information (all 15)
    ORTHOLOGY for yes1 ( Chr: 2 )
    CITATIONS (33)