Gene

casr

ID
ZDB-GENE-050119-8
Name
calcium-sensing receptor
Symbol
casr Nomenclature History
Previous Names
  • CaSR (1)
  • casrl
  • zmp:0000001046
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have G protein-coupled receptor activity. Involved in calcium ion homeostasis and skeletal system development. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Is expressed in several structures, including head; integument; nervous system; notochord; and pleuroperitoneal region. Orthologous to human CASR (calcium sensing receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With casr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant hypocalcemia 1 Alliance Hypocalcemia, autosomal dominant 601198
autosomal dominant hypocalcemia 1 Alliance Hypocalcemia, autosomal dominant, with Bartter syndrome 601198
familial hypocalciuric hypercalcemia 1 Alliance Hypocalciuric hypercalcemia, type I 145980
idiopathic generalized epilepsy 8 Alliance {Epilepsy idiopathic generalized, susceptibility to, 8} 612899
Hyperparathyroidism, neonatal 239200
Associated With casr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001828 Receptor, ligand binding region
Domain IPR011500 GPCR, family 3, nine cysteines domain
Domain IPR017978 GPCR family 3, C-terminal
Family IPR000068 GPCR, family 3, extracellular calcium-sensing receptor-related
Family IPR000337 GPCR, family 3
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Homologous_superfamily IPR038550 GPCR, family 3, nine cysteines domain superfamily
Domain Details Per Protein
Protein Length GPCR, family 3 GPCR family 3, C-terminal GPCR, family 3, extracellular calcium-sensing receptor-related GPCR, family 3, nine cysteines domain GPCR, family 3, nine cysteines domain superfamily Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:F1R4B8 944
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-casr polyclonal Rabbit
  • IHC
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations