ZFIN ID: ZDB-GENE-050119-2
Gene Name: low density lipoprotein receptor-related protein 2a
Gene Symbol: lrp2a
Sequence Ontology ID : SO:0000704

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Previous Names: lrp2 (1), gp330b, im:680590, megalin (1)

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(Including Attributions)
Location: Chr: 9 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have calcium ion binding activity; involved in receptor-mediated endocytosis and renal absorption; predicted to localize to the integral component of membrane; orthologous to human LRP2  ...
GENE EXPRESSION
All Expression Data: 18 figures from 7 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Juvenile:Days 30-44 (30d-45d, 10 mm, adult fins/pigment)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016624Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027052Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • mw1 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • p5bnc Point Mutation Unknown Premature Stop ENU
    sa25 Point Mutation Unknown Splice Site ENU
    sa17023 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18967 Point Mutation Unknown Splice Site ENU
    sa21599 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21600 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25440 Point Mutation Unknown Premature Stop ENU
    sa34763 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34764 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34765 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34766 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38765 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41550 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41551 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 20 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH lrp2a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Donnai-Barrow syndrome Donnai-Barrow syndrome 222448
    DISEASE ASSOCIATED WITH lrp2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process receptor-mediated endocytosis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000033 (1)
  • InterPro:IPR000152 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR002172 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011042 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR018097 (1)
  • InterPro:IPR023415 (1)
  • InterPro:IPR026823 (1)
  • InterPro:IPR032485 (1)
  • InterPro:IPR036055 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS01209 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50068 (1)
  • PROSITE:PS51120 (1)
  • Pfam:PF00057 (1)
  • Pfam:PF00058 (1)
  • Pfam:PF07645 (1)
  • Pfam:PF12662 (1)
  • Pfam:PF16472 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA lrp2a-001 (1) 17239
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM lrp2a No data available
    MARKER RELATIONSHIPS
    lrp2aContained in: [BAC] CH73-81D5 (1) (order this), CH211-121K8 (1) (order this)
    [Fosmid] CH1073-311N13 (1) (order this), CH1073-380O14 (1) (order this)
    lrp2aContains: [STS] zfishfos432h10.q1k (1)
    lrp2aEncodes: [EST] IMAGE:680590 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001194987 (1) 14283bp
    Genomic GenBank:BX927361 (1) 177986bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IAG0 (1) 4673aa
    Sequence Clusters UniGene:86548 (1)
    Sequence Information (all 26)
    OTHER lrp2a GENE PAGES
  • Alliance (1)
  • Gene:568184 (1)
  • VEGA:OTTDARG00000036529 (1)
  • Ensembl(GRCz11):ENSDARG00000102506 (1)
  • ORTHOLOGY for lrp2a (Chr: 9)
    CITATIONS (40)