ZFIN ID: ZDB-GENE-050116-2
Gene Name: protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a
Gene Symbol: prkar1aa
Previous Names: prkar1a, im:7047729, zgc:92515
Location: Chr: 3   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from Kotani et al., 2010
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
  early embryonic cell Golgi apparatus, early embryonic cell cytoplasm, immature eye cytoplasm, neural tube cytoplasm (all 6) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-prkar1aa (1)

Allele Type Mutagen Suppliers
sa10163 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: Fig. 4 from Kotani et al., 2010
    Observed in: protein kinase activity
    DISEASE ASSOCIATED WITH prkar1aa HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    acrodysostosis Acrodysostosis 1, with or without hormone resistance 101800
    Carney complex Carney complex, type 1 160980
    primary pigmented nodular adrenocortical disease Pigmented nodular adrenocortical disease, primary, 1 610489
    papillary thyroid carcinoma Thyroid carcinoma, papillary, somatic 188550
    Myxoma, intracardiac 255960
    Adrenocortical tumor, somatic,
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component cAMP-dependent protein kinase complex (more)
    Molecular Function cAMP-dependent protein kinase regulator activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000595 (1)
  • InterPro:IPR002373 (1)
  • InterPro:IPR003117 (1)
  • InterPro:IPR012198 (1)
  • InterPro:IPR014710 (1)
  • InterPro:IPR018488 (1)
  • InterPro:IPR018490 (1)
  • PROSITE:PS00888 (1)
  • PROSITE:PS00889 (1)
  • PROSITE:PS50042 (1)
  • Pfam:PF00027 (1)
  • Pfam:PF02197 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA prkar1aa-001 (1) 3964
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES
    Ab1-prkar1aa (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prkar1aa No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    prkar1aa Contained in: [BAC] CH211-117C2 (1) (order this), CH211-234H8 (1) (order this)
    prkar1aa Encodes: [EST] IMAGE:7047729 (1)
    [cDNA] MGC:92515 (1) (order this), MGC:158152 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001009989 (1) 4026 bp
    Genomic GenBank:BX897685 (1) 179286 bp
    Select Tool
    Polypeptide UniProtKB:Q5I0F6 (1) 379 aa
    Sequence Clusters UniGene:85613 (1)
    Sequence Information (all 16)
    OTHER prkar1aa GENE PAGES
  • Gene:494533 (1)
  • VEGA:OTTDARG00000019318 (1)
  • Ensembl(Zv9):ENSDARG00000076128 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish prkar1aa 3  
    Human PRKAR1A 17 (17q24.2)
  • OMIM:188830
  • Gene:5573
  • Orthology Details
    CITATIONS (15)