ZFIN ID: ZDB-GENE-050116-2
Gene Name: protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a
Gene Symbol: prkar1aa
Previous Names: prkar1a, im:7047729, zgc:92515
Location: Chr: 3   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from Kotani et al., 2010
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
  early embryonic cell Golgi apparatus, early embryonic cell cytoplasm, immature eye cytoplasm, neural tube cytoplasm (all 6) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa10163
Knockdown reagents: MO1-prkar1aa (1)
PHENOTYPE
Data: Fig. 4 from Kotani et al., 2010
Observed in: protein kinase activity

Phenotype of Human Orthologue OMIM Phenotype ID
Acrodysostosis 1, with or without hormone resistance 101800
Adrenocortical tumor, somatic,
Carney complex, type 1 160980
Myxoma, intracardiac 255960
Pigmented nodular adrenocortical disease, primary, 1 610489
Thyroid carcinoma, papillary, somatic 188550
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphorylation (more)
Cellular Component cAMP-dependent protein kinase complex (more)
Molecular Function cAMP-dependent protein kinase regulator activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000595 (1)
  • InterPro:IPR002373 (1)
  • InterPro:IPR003117 (1)
  • InterPro:IPR012198 (1)
  • InterPro:IPR014710 (1)
  • InterPro:IPR018488 (1)
  • InterPro:IPR018490 (1)
  • PROSITE:PS00888 (1)
  • PROSITE:PS00889 (1)
  • PROSITE:PS50042 (1)
  • Pfam:PF00027 (1)
  • Pfam:PF02197 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA prkar1aa-001 (1) 3964
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES
    Ab1-prkar1aa (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prkar1aa No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    prkar1aa Contained in: [BAC] CH211-117C2 (1) (order this), CH211-234H8 (1) (order this)
    prkar1aa Encodes: [EST] IMAGE:7047729 (1)
    [cDNA] MGC:92515 (1) (order this), MGC:158152 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001009989 (1) 4026 bp
    Genomic GenBank:BX897685 (1) 179286 bp
    Select Tool
    Polypeptide UniProtKB:Q5I0F6 (1) 379 aa
    Sequence Clusters UniGene:85613 (1)
    Sequence Information (all 16)
    OTHER prkar1aa GENE PAGES
  • Gene:494533 (1)
  • VEGA:OTTDARG00000019318 (1)
  • Ensembl(Zv9):ENSDARG00000076128 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish prkar1aa 3  
    Human PRKAR1A 17 (17q24.2)
  • OMIM:188830
  • Gene:5573
  • Orthology Details
    CITATIONS (15)