ZFIN ID: ZDB-GENE-050116-2
Gene Name: protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a
Gene Symbol: prkar1aa
Previous Names: prkar1a, im:7047729, zgc:92515
Location: Chr: 3 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from Kotani et al., 2010
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
  early embryonic cell Golgi apparatus, early embryonic cell cytoplasm, immature eye cytoplasm, neural tube cytoplasm (all 6) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
sa10163 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-prkar1aa (1)
    PHENOTYPE
    Data: Fig. 4 from Kotani et al., 2010
    Observed in: protein kinase activity
    DISEASE ASSOCIATED WITH prkar1aa HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    acrodysostosis Acrodysostosis 1, with or without hormone resistance 101800
    Carney complex Carney complex, type 1 160980
    primary pigmented nodular adrenocortical disease Pigmented nodular adrenocortical disease, primary, 1 610489
    Myxoma, intracardiac 255960
    Adrenocortical tumor, somatic,
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component cAMP-dependent protein kinase complex (more)
    Molecular Function cAMP-dependent protein kinase regulator activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000595 (1)
  • InterPro:IPR003117 (1)
  • InterPro:IPR012198 (1)
  • InterPro:IPR014710 (1)
  • InterPro:IPR018488 (1)
  • InterPro:IPR018490 (1)
  • PROSITE:PS00888 (1)
  • PROSITE:PS00889 (1)
  • PROSITE:PS50042 (1)
  • Pfam:PF00027 (1)
  • Pfam:PF02197 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA prkar1aa-001 (1) 3964
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES 
    Ab1-prkar1aa (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prkar1aa No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    prkar1aaContained in: [BAC] CH211-117C2 (1) (order this), CH211-234H8 (1) (order this)
    prkar1aaEncodes: [EST] IMAGE:7047729 (1)
    [cDNA] MGC:92515 (1) (order this), MGC:158152 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001009989 (1) 4026bp
    Genomic GenBank:BX897685 (1) 179286bp
    Select Tool
    Polypeptide UniProtKB:Q5I0F6 (1) 379aa
    Sequence Clusters UniGene:85613 (1)
    Sequence Information (all 16)
    OTHER prkar1aa GENE PAGES 
  • Gene:494533 (1)
  • VEGA:OTTDARG00000019318 (1)
  • Ensembl(GRCz10):ENSDARG00000076128 (1)
  • ORTHOLOGY for prkar1aa (Chr: 3) 
    Species Symbol Chromosome Accession # Evidence
    Human PRKAR1A 17
  • Gene:5573
  • OMIM:188830
  • HGNC:9388
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (15)