ZFIN ID: ZDB-GENE-050106-1
Gene Name: transient receptor potential cation channel, subfamily A, member 1b
Gene Symbol: trpa1b    Nomenclature History

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Previous Names: trpa1l (1), trpa2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits calcium-release channel activity. Involved in chemosensory behavior; detection of chemical stimulus involved in sensory perception of pain; and ion transmembrane transport. Predicted to localize to integral component of membrane. Is expressed in Rohon-Beard neurons and cranial ganglion. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1).
Genome Resources: Alliance (1),  Gene:474353 (1),  Ensembl(GRCz11):ENSDARG00000031875 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9365 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11221 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16565 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30061 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37842 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vu197 Point Mutation Unknown Unknown
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2182 Insertion Unknown Unknown CRISPR
    zf2184 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-trpa1b 1
    MO1-trpa1b N/A 2
    MO2-trpa1b N/A 1
    PHENOTYPE
    Data: Fig. 2 from Faucherre et al., 2013
    Observed in:
    DISEASE ASSOCIATED WITH trpa1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial episodic pain syndrome 1 Alliance ?Episodic pain syndrome, familial, 1 615040
    DISEASE ASSOCIATED WITH trpa1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process detection of chemical stimulus involved in sensory perception (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium-release channel activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA trpa1b-201 (1)    Ensembl 4100
    trpa1b-202 (1)    Ensembl 3324
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM trpa1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(myl7:trpa1b-2A-EGFP) myl7 2AEGFPtrpa1b Danio rerio 1 1
    Tg(trpa1b:EGFP) trpa1b EGFP Danio rerio 1 4
    TgBAC(trpa1b:EGFP) trpa1b EGFP Danio rerio 1 7
    MARKER RELATIONSHIPS
    trpa1b Contained in: [BAC] CH211-269F16 (1), DKEY-112N9 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007066 (1) 4130 nt
    Genomic GenBank:CR450741 (1) 157603 nt
    Select Tool
    Polypeptide UniProtKB:F1R8I6 (1) 1120 aa
    Sequence Information (all 17)
    ORTHOLOGY for trpa1b ( Chr: 24 )
    CITATIONS (37)