Gene

trpa1b

ID

ZDB-GENE-050106-1

Name

transient receptor potential cation channel, subfamily A, member 1b

Symbol

trpa1b Nomenclature History

Previous Names

trpa1l (1)
trpa2 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Enables intracellularly gated calcium channel activity. Acts upstream of or within chemosensory behavior; detection of chemical stimulus involved in sensory perception of pain; and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in Rohon-Beard neurons and cranial ganglion. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Faucherre et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trpa1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial episodic pain syndrome 1	Alliance	?Episodic pain syndrome, familial, 1	615040

Associated With trpa1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Family	IPR052076	Transient receptor potential cation channel
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:B6D5I5	InterPro	1107
UniProtKB:Q5UM14	InterPro	1120
UniProtKB:A0A8M9PU11	InterPro	985

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	trpa1b-201 (1) Ensembl	Ensembl	4,100 nt	Select Tool ZFIN BLAST
mRNA	trpa1b-202 (1) Ensembl	Ensembl	3,324 nt	Select Tool ZFIN BLAST
mRNA	trpa1b-203 (1) Ensembl	Ensembl	5,993 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations