ZFIN Gene: trpa1b

ZFIN ID: ZDB-GENE-050106-1

ZFIN ID: ZDB-GENE-050106-1

Gene Name:

transient receptor potential cation channel, subfamily A, member 1b

Gene Symbol:

trpa1b Nomenclature History

Previous Names:

trpa1l (1), trpa2 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 24 Mapping Details/Browsers

Description:

Exhibits calcium-release channel activity. Involved in chemosensory behavior; detection of chemical stimulus involved in sensory perception of pain; and ion transmembrane transport. Predicted to localize to integral component of membrane. Is expressed in Rohon-Beard neurons and cranial ganglion. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1).

Genome Resources:

Alliance (1), Gene:474353 (1), Ensembl(GRCz11):ENSDARG00000031875 (2)

GENE EXPRESSION
All Expression Data:	13 figures from 8 publications
Wild-type Stages, Structures:	Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
	cranial ganglion epibranchial ganglion facial ganglion glossopharyngeal ganglion Rohon-Beard neuron trigeminal ganglion sensory neuron trigeminal ganglion vagal ganglion 1 vagal ganglion 2 vagal ganglion 3 vagal ganglion 4 whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa9365	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa11221	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16565	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa30061	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37842	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
vu197	Point Mutation	Unknown	Unknown		Zebrafish International Resource Center (ZIRC) (order this)
zf2182	Insertion	Unknown	Unknown	CRISPR
zf2184	Small Deletion	Unknown	Unknown	CRISPR

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-trpa1b	zf2182 zf2184	1
MO1-trpa1b	N/A	2
MO2-trpa1b	N/A	1

PHENOTYPE

Data:	Fig. 2 from Faucherre et al., 2013
Observed in:	chemosensory behavior

DISEASE ASSOCIATED WITH trpa1b HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial episodic pain syndrome 1	Alliance	?Episodic pain syndrome, familial, 1	615040

DISEASE ASSOCIATED WITH trpa1b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	detection of chemical stimulus involved in sensory perception (more)
Cellular Component	integral component of membrane (more)
Molecular Function	calcium-release channel activity (more)

GO Terms (all 17)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	trpa1b-201 (1)	4100	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	trpa1b-202 (1)	3324	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM trpa1b

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(myl7:trpa1b-2A-EGFP)	myl7	2A, EGFP, trpa1b	Danio rerio	1	1
Tg(trpa1b:EGFP)	trpa1b	EGFP	Danio rerio	1	4
TgBAC(trpa1b:EGFP)	trpa1b	EGFP	Danio rerio	1	7

MARKER RELATIONSHIPS

trpa1b Contained in:

[BAC] CH211-269F16 (1), DKEY-112N9 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001007066 (1)	4130 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR450741 (1)	157603 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1R8I6 (1)	1120 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 17)

ORTHOLOGY for trpa1b ( Chr: 24 )

CITATIONS (37)

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