ZFIN ID: ZDB-GENE-050105-1
Gene Name: nuclear receptor subfamily 1, group d, member 1
Gene Symbol: nr1d1    Nomenclature History

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Previous Names: ear1 (1), Reverbalpha (1), zrev-erba (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in autophagy; circadian regulation of gene expression; and regulation of locomotor rhythm. Localizes to the chromatin. Is expressed in nervous system. Orthologous to human NR1D1 (nuclear receptor subfamily 1 group D member 1).
Genome Resources: Alliance (1),  Gene:494487 (1),  Ensembl(GRCz11):ENSDARG00000033160 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19994 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sus010 Small Deletion Exon 2 Frameshift TALEN
    sus012 Indel Exon 2 Frameshift TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nr1d1 N/A 1
    MO2-nr1d1 N/A 1
    TALEN1-nr1d1 1
    DISEASE ASSOCIATED WITH nr1d1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nr1d1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of gene expression (more)
    Cellular Component chromatin (more)
    Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
    Domain IPR001628 Zinc finger, nuclear hormone receptor-type
    Family IPR001723 Nuclear hormone receptor
    Family IPR001728 Thyroid hormone receptor
    Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
    Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nr1d1-201 (1)    Ensembl 2926
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-nr1d1 polyclonal Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nr1d1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(nr1d1-Mmu.Fos:EGFP) nr1d1 EGFP Danio rerioMus musculus 2 1
    MARKER RELATIONSHIPS
    nr1d1 Contained in: [BAC] DKEY-225F5 (1) (order this)
    nr1d1 Encodes: [EST] ay391444 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_205729 (1) 2803 nt
    Genomic GenBank:BX682558 (1) 146807 nt
    Select Tool
    Polypeptide UniProtKB:F1RAU6 (1) 637 aa
    Sequence Information (all 15)
    ORTHOLOGY for nr1d1 ( Chr: 3 )
    CITATIONS (65)