ZFIN ID: ZDB-GENE-041212-81
Gene Name: cholesterol 25-hydroxylase
Gene Symbol: ch25h    Nomenclature History

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Previous Names: ch25hb (1), zgc:101688 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have C-4 methylsterol oxidase activity and cholesterol 25-hydroxylase activity. Involved in defense response to virus. Predicted to localize to endoplasmic reticulum membrane. Is expressed in gill; intestine; kidney; liver; and spleen. Orthologous to human CH25H (cholesterol 25-hydroxylase).
Genome Resources: Alliance (1),  Gene:494109 (1),  Ensembl(GRCz11):ENSDARG00000045190 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:101688]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012125Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ch25h
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ch25h HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ch25h VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process defense response to virus (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function cholesterol 25-hydroxylase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ch25h-201 (1)    Ensembl 1121
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ch25h No data available
    MARKER RELATIONSHIPS
    ch25h Contained in: [BAC] DKEY-26G8 (1) (order this)
    ch25h Encodes: [cDNA] MGC:101688 (1), MGC:192291 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001008652 (1) 1134 nt
    Genomic GenBank:BX000534 (1) 199670 nt
    Select Tool
    Polypeptide UniProtKB:B2GRG2 (1) 251 aa
    Sequence Information (all 20)
    ORTHOLOGY for ch25h ( Chr: 12 )
    CITATIONS (34)