ZFIN ID: ZDB-GENE-041212-70
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Gene Name: epoxide hydrolase 2, cytoplasmic
Gene Symbol: ephx2    Nomenclature History

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Previous Names: cb523 (1), sb:cb523, zgc:101645

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits epoxide hydrolase activity. Involved in hematopoietic progenitor cell differentiation and venous blood vessel development. Predicted to localize to the peroxisome. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Is expressed in cardiovascular system; digestive system; neural tube; somite; and spinal cord. Orthologous to human EPHX2 (epoxide hydrolase 2).
Genome Resources: Alliance (1),  Gene:494099 (1),  Ensembl(GRCz11):ENSDARG00000040255 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 4 figures (7 images) from Thisse et al., 2001 [cb523]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027890Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa6457 Point Mutation Unknown Splice Site ENU
    sa14928 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa28783 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa36296 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42857 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ephx2 N/A 1
    MO2-ephx2 N/A 1
    MO3-ephx2 N/A 1
    PHENOTYPE
    Data: 2 figures from Frömel et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH ephx2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial hypercholesterolemia Alliance {Hypercholesterolemia, familial, due to LDLR defect, modifier of} 143890
    DISEASE ASSOCIATED WITH ephx2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic progenitor cell differentiation (more)
    Cellular Component peroxisome (more)
    Molecular Function epoxide hydrolase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000073 Alpha/beta hydrolase fold-1
    Family IPR000639 Epoxide hydrolase-like
    Homologous_superfamily IPR023198 Phosphoglycolate phosphatase-like, domain 2
    Homologous_superfamily IPR023214 HAD superfamily
    Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
    Homologous_superfamily IPR036412 HAD-like superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ephx2-201 (1)    Ensembl 2170
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ephx2 No data available
    MARKER RELATIONSHIPS
    ephx2 Contained in: [BAC] CH73-339L24 (1)
    ephx2 Encodes: [EST] cb523 (1) (order this)
    [cDNA] MGC:101645 (1), MGC:193034 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001008642 (1) 2218 bp
    Select Tool
    Genomic GenBank:CU571076 (1) 100888 bp
    Select Tool
    Polypeptide UniProtKB:F1R264 (1) 557 aa
    Select Tool
    Sequence Information (all 15)
    ORTHOLOGY for ephx2 ( Chr: 17 )
    CITATIONS (26)