Gene
ephx2
- ID
- ZDB-GENE-041212-70
- Name
- epoxide hydrolase 2, cytoplasmic
- Symbol
- ephx2 Nomenclature History
- Previous Names
-
- cb523 (1)
- sb:cb523
- zgc:101645
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables epoxide hydrolase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and venous blood vessel development. Predicted to be located in cytoplasm. Predicted to be active in peroxisome. Is expressed in cardiovascular system; digestive system; neural tube; somite; and spinal cord. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (epoxide hydrolase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb523 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Frömel et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypercholesterolemia | Alliance | {Hypercholesterolemia, familial, due to LDLR defect, modifier of} | 143890 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000073 | Alpha/beta hydrolase fold-1 |
| Family | IPR000639 | Epoxide hydrolase-like |
| Homologous_superfamily | IPR023198 | Phosphoglycolate phosphatase-like, domain 2 |
| Homologous_superfamily | IPR023214 | HAD superfamily |
| Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
| Homologous_superfamily | IPR036412 | HAD-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | Alpha/beta hydrolase fold-1 | Epoxide hydrolase-like | HAD-like superfamily | HAD superfamily | Phosphoglycolate phosphatase-like, domain 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5PRC6 | InterPro | 557 | ||||||
| UniProtKB:A0A8M9P8W1 | InterPro | 525 |
Interactions and Pathways
No data available
Plasmids
No data available