Gene
ephx2
- ID
- ZDB-GENE-041212-70
- Name
- epoxide hydrolase 2, cytoplasmic
- Symbol
- ephx2 Nomenclature History
- Previous Names
-
- cb523 (1)
- sb:cb523
- zgc:101645
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Exhibits epoxide hydrolase activity. Involved in hematopoietic progenitor cell differentiation and venous blood vessel development. Predicted to localize to peroxisome. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Is expressed in cardiovascular system; digestive system; neural tube; somite; and spinal cord. Orthologous to human EPHX2 (epoxide hydrolase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb523 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Frömel et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypercholesterolemia | Alliance | {Hypercholesterolemia, familial, due to LDLR defect, modifier of} | 143890 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000073 | Alpha/beta hydrolase fold-1 |
| Family | IPR000639 | Epoxide hydrolase-like |
| Homologous_superfamily | IPR023198 | Phosphoglycolate phosphatase-like, domain 2 |
| Homologous_superfamily | IPR023214 | HAD superfamily |
| Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
| Homologous_superfamily | IPR036412 | HAD-like superfamily |
Domain Details Per Protein
| Protein | Length | Alpha/Beta hydrolase fold | Alpha/beta hydrolase fold-1 | Epoxide hydrolase-like | HAD-like superfamily | HAD superfamily | Phosphoglycolate phosphatase-like, domain 2 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5PRC6
|
557 | ||||||
|
UniProtKB:A0A8M9P8W1
|
525 |
Interactions and Pathways
No data available
Plasmids
No data available