ZFIN Gene: ephx2

ZFIN ID: ZDB-GENE-041212-70

ZFIN ID: ZDB-GENE-041212-70

Gene Name:

epoxide hydrolase 2, cytoplasmic

Gene Symbol:

ephx2 Nomenclature History

Previous Names:

cb523 (1), sb:cb523, zgc:101645

Gene Type:

protein_coding_gene

Location:

Chr: 17 Mapping Details/Browsers

Description:

Exhibits epoxide hydrolase activity. Involved in hematopoietic progenitor cell differentiation and venous blood vessel development. Predicted to localize to peroxisome. Is expressed in cardiovascular system; digestive system; neural tube; somite; and spinal cord. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (epoxide hydrolase 2).

Genome Resources:

Alliance (1), Gene:494099 (1), Ensembl(GRCz11):ENSDARG00000040255 (2)

GENE EXPRESSION
Directly Submitted Expression Data:	4 figures (7 images) from Thisse et al., 2001 [cb523]
Wild-type Stages, Structures:	Segmentation:14-19 somites (16.0h-19.0h) to Hatching:Long-pec (48.0h-60.0h)
	cardiovascular system gut liver neural tube somite spinal cord

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la027890Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa6457	Point Mutation	Unknown	Splice Site	ENU
sa14928	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa28783	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa36296	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42857	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-ephx2	N/A	1
MO2-ephx2	N/A	1
MO3-ephx2	N/A	1

PHENOTYPE

Data:	2 figures from Frömel et al., 2012
Observed in:	caudal vein plexus eye parachordal vessel

DISEASE ASSOCIATED WITH ephx2 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial hypercholesterolemia	Alliance	{Hypercholesterolemia, familial, due to LDLR defect, modifier of}	143890

DISEASE ASSOCIATED WITH ephx2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	hematopoietic progenitor cell differentiation (more)
Cellular Component	peroxisome (more)
Molecular Function	epoxide hydrolase activity (more)

GO Terms (all 10)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	ephx2-201 (1)	2170	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM ephx2 No data available

MARKER RELATIONSHIPS

ephx2 Contained in:	[BAC] CH73-339L24 (1)
ephx2 Encodes:	[EST] cb523 (1) (order this) [cDNA] MGC:101645 (1), MGC:193034 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001008642 (1)	2218 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU571076 (1)	100888 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1R264 (1)	557 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 15)

ORTHOLOGY for ephx2 ( Chr: 17 )

CITATIONS (26)

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