ZFIN ID: ZDB-GENE-041212-70
Gene Name: epoxide hydrolase 2, cytoplasmic
Gene Symbol: ephx2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cb523 (1), sb:cb523, zgc:101645

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits epoxide hydrolase activity. Involved in hematopoietic progenitor cell differentiation and venous blood vessel development. Predicted to localize to peroxisome. Is expressed in cardiovascular system; digestive system; neural tube; somite; and spinal cord. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (epoxide hydrolase 2).
Genome Resources: Alliance (1),  Gene:494099 (1),  Ensembl(GRCz11):ENSDARG00000040255 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027890Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6457 Point Mutation Unknown Splice Site ENU
    sa14928 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28783 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36296 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42857 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ephx2 N/A 1
    MO2-ephx2 N/A 1
    MO3-ephx2 N/A 1
    DISEASE ASSOCIATED WITH ephx2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial hypercholesterolemia Alliance {Hypercholesterolemia, familial, due to LDLR defect, modifier of} 143890
    DISEASE ASSOCIATED WITH ephx2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic progenitor cell differentiation (more)
    Cellular Component peroxisome (more)
    Molecular Function epoxide hydrolase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ephx2-201 (1)    Ensembl 2170
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ephx2 No data available
    MARKER RELATIONSHIPS
    ephx2 Contained in: [BAC] CH73-339L24 (1)
    ephx2 Encodes: [EST] cb523 (1) (order this)
    [cDNA] MGC:101645 (1), MGC:193034 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001008642 (1) 2218 nt
    Genomic GenBank:CU571076 (1) 100888 nt
    Select Tool
    Polypeptide UniProtKB:F1R264 (1) 557 aa
    Sequence Information (all 15)
    ORTHOLOGY for ephx2 ( Chr: 17 )
    CITATIONS (26)