ZFIN ID: ZDB-GENE-041212-26
Gene Name: pseudouridine synthase 1
Gene Symbol: pus1    Nomenclature History

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Previous Names: wu:fb98h11, zgc:103516

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1).
Genome Resources: Alliance (1),  Gene:494060 (1),  Ensembl(GRCz11):ENSDARG00000045562 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:5411761]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7161210]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pus1 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH pus1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
myopathy, lactic acidosis, and sideroblastic anemia 1 Alliance Myopathy, lactic acidosis, and sideroblastic anemia 1 600462
DISEASE ASSOCIATED WITH pus1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process pseudouridine synthesis (more)
Cellular Component nucleus (more)
Molecular Function pseudouridine synthase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pus1-201 (1)    Ensembl 881
pus1-202 (1)    Ensembl 1539
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pus1 No data available
MARKER RELATIONSHIPS
pus1 Contained in: [BAC] DKEY-11O18 (1) (order this)
pus1 Encodes: [EST] fb98h11, IMAGE:5411761 (1), IMAGE:7161210 (1)
[cDNA] MGC:103516 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001008603 (1) 1460 nt
Genomic GenBank:CR450803 (1) 150034 nt
Select Tool
Polypeptide UniProtKB:F1QWW1 (1) 412 aa
Sequence Information (all 16)
ORTHOLOGY for pus1 ( Chr: 21 )
CITATIONS (19)