ZFIN ID: ZDB-GENE-041210-5
Gene Name: SIM bHLH transcription factor 1b
Gene Symbol: sim1b    Nomenclature History

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Previous Names: Sim1 (1), si:ch211-152c2.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in obesity. Is expressed in caudal tuberculum; diencephalon; hypothalamus; midbrain; and preoptic area. Orthologous to human SIM1 (SIM bHLH transcription factor 1).
Genome Resources: Alliance (1),  Gene:566656 (1),  Ensembl(GRCz11):ENSDARG00000013789 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14238 Point Mutation Unknown Missense, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sim1b N/A 1
    MO2-sim1b N/A 1
    MO3-sim1b N/A 1
    MO4-sim1b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sim1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sim1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component cytoplasm (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000014 PAS domain
    Family IPR001067 Nuclear translocator
    Repeat IPR001610 PAC motif
    Domain IPR010578 Single-minded, C-terminal
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Domain IPR013655 PAS fold-3
    Domain IPR013767 PAS fold
    Homologous_superfamily IPR035965 PAS domain superfamily
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript sim1b-202 (1)    Ensembl 816
    mRNA sim1b-201 (1)    Ensembl 1761
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sim1b No data available
    MARKER RELATIONSHIPS
    sim1b Contained in: [BAC] CH211-152C2 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001159585 (1) 1761 bp
    Genomic GenBank:BX649468 (1) 164705 bp
    Select Tool
    Polypeptide UniProtKB:C1JIE2 (1) 586 aa
    Sequence Information (all 15)
    ORTHOLOGY for sim1b ( Chr: 4 )
    CITATIONS (18)