ZFIN ID: ZDB-GENE-041118-20
Gene Name: dishevelled segment polarity protein 2
Gene Symbol: dvl2    Nomenclature History

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Previous Names: sb:eu471, wu:fc05d12, wu:fo71e09, wu:fp54a02, zgc:55372

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have frizzled binding activity. Involved in several processes, including cell migration in hindbrain; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Localizes to the cell cortex and spindle. Is expressed in liver. Orthologous to human DVL2 (dishevelled segment polarity protein 2).
Genome Resources: Alliance (1),  Gene:323630 (1),  Ensembl(GRCz11):ENSDARG00000056184 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55372]
  1 figure (1 image) from Thisse et al., 2005 [eu471]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016032Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029293Tg Transgenic Insertion Unknown Unknown DNA
    sa6076 Point Mutation Unknown Premature Stop ENU
    sa20904 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40866 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sdu15 Small Deletion Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dvl2 N/A 10
    MO2-dvl2 N/A 1
    MO3-dvl2 N/A 1
    TALEN1-dvl2 2
    DISEASE ASSOCIATED WITH dvl2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dvl2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in axis elongation (more)
    Cellular Component cell cortex (more)
    Molecular Function protein binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000591 DEP domain
    Domain IPR001158 DIX domain
    Domain IPR001478 PDZ domain
    Domain IPR003351 Dishevelled protein domain
    Family IPR008339 Dishevelled family
    Family IPR008341 Dishevelled-2
    Family IPR015506 Dishevelled-related protein
    Domain IPR024580 Dishevelled C-terminal
    Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
    Homologous_superfamily IPR036034 PDZ superfamily
    Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
    Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
    Homologous_superfamily IPR038207 DIX domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dvl2-201 (1)    Ensembl 4848
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-dvl2 polyclonal Rabbit 1
    CONSTRUCTS WITH SEQUENCES FROM dvl2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(nkx2.3:EGFP-dvl2) nkx2.3 dvl2EGFP Danio rerio 1 2
    Tg(UAS:dndvl2,cryaa:Cerulean) cryaaUAS Ceruleandvl2 Danio rerio 1 3
    MARKER RELATIONSHIPS
    dvl2 Contained in: [BAC] CH73-335L21 (1), DKEY-33C9 (1) (order this)
    dvl2 Encodes: [EST] eu471 (1), fc05d12 (1), fp54a02 (1)
    [cDNA] MGC:55372 (1)
    dvl2 Has Artifact: [EST] fo71e09 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212648 (1) 2604 bp
    Genomic GenBank:CR376787 (1) 217684 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QM97 (1) 747 aa
    Sequence Information (all 19)
    ORTHOLOGY for dvl2 ( Chr: 7 )
    CITATIONS (63)