ZFIN Gene: cbl

ZFIN ID: ZDB-GENE-041114-207

ZFIN ID: ZDB-GENE-041114-207

Gene Name:

Cbl proto-oncogene, E3 ubiquitin protein ligase

Gene Symbol:

cbl

Sequence Ontology ID :

SO:0001217

Previous Names:

wu:fd16a12, zgc:92560 (1)

Location:

Chr: 15 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in definitive hemopoiesis. Predicted to localize to the ...

GENE EXPRESSION
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:92560]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la012697Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
rj32	Point Mutation	Exon 8	Missense	ENU
sa15300	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35879	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42540	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	4 figures from Peng et al., 2015
Observed in:	basophilic erythroblast caudal hematopoietic tissue myeloid cell caudal hematopoietic tissue nucleate erythrocyte caudal hematopoietic tissue head kidney myeloid cell head kidney hematopoietic stem cell cell population proliferation myeloid cell cell population proliferation nucleate erythrocyte pronephros monocyte whole organism

DISEASE ASSOCIATED WITH cbl HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
juvenile myelomonocytic leukemia	?Juvenile myelomonocytic leukemia	607785
	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	613563

DISEASE ASSOCIATED WITH cbl VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
myeloproliferative neoplasm	cbl^rj32/rj32(TU)	standard conditions	Peng et al., 2015

GENE ONTOLOGY

Ontology	GO Term
Biological Process	definitive hemopoiesis (more)
Cellular Component	membrane raft (more)
Molecular Function	calcium ion binding (more)

GO Terms (all 14)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001841 (1) InterPro:IPR003153 (1) InterPro:IPR009060 (1) InterPro:IPR011992 (1) InterPro:IPR013083 (1) InterPro:IPR014741 (1) InterPro:IPR014742 (1) InterPro:IPR015940 (1) InterPro:IPR017907 (1) InterPro:IPR024159 (1) InterPro:IPR024162 (1) InterPro:IPR036537 (1) InterPro:IPR036860 (1) InterPro:IPR039520 (1)	PROSITE:PS00518 (1) PROSITE:PS50030 (1) PROSITE:PS50089 (1) PROSITE:PS51506 (1)	Pfam:PF02262 (1) Pfam:PF02761 (1) Pfam:PF02762 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	cbl-201 (1)	4069	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION No description available

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM cbl No data available

MARKER RELATIONSHIPS

cbl Contained in:	[BAC] DKEY-257C10 (1) (order this)
cbl Encodes:	[EST] fd16a12 [cDNA] MGC:92560 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001007330 (1)	4023 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571886 (1)	178049 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QI90 (1)	913 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:78552 (1)

Sequence Information (all 14)

OTHER cbl GENE PAGES

Alliance (1)

Gene:492364 (1)

VEGA:OTTDARG00000022950 (1)

Ensembl(GRCz11):ENSDARG00000009958 (2)

ORTHOLOGY for cbl ( Chr: 15 )

CITATIONS (27)

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