ZFIN ID: ZDB-GENE-041114-207
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Gene Name: Cbl proto-oncogene, E3 ubiquitin protein ligase
Gene Symbol: cbl
Sequence Ontology ID : SO:0000704

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Previous Names: wu:fd16a12, zgc:92560 (1)

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(Including Attributions)
Location: Chr: 15 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92560]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012697Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • rj32 Point Mutation Exon 8 Missense ENU
    sa15300 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35879 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42540 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: 4 figures from Peng et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH cbl HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    juvenile myelomonocytic leukemia ?Juvenile myelomonocytic leukemia 607785
    Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia 613563
    DISEASE ASSOCIATED WITH cbl VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    myeloproliferative neoplasm cblrj32/rj32(TU) standard conditions Peng et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component membrane raft (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001841 (1)
  • InterPro:IPR003153 (1)
  • InterPro:IPR009060 (1)
  • InterPro:IPR011992 (1)
  • InterPro:IPR013083 (1)
  • InterPro:IPR014741 (1)
  • InterPro:IPR014742 (1)
  • InterPro:IPR015940 (1)
  • InterPro:IPR017907 (1)
  • InterPro:IPR024159 (1)
  • InterPro:IPR024162 (1)
  • InterPro:IPR036537 (1)
  • InterPro:IPR036860 (1)
  • InterPro:IPR039520 (1)
    		•
  • PROSITE:PS00518 (1)
  • PROSITE:PS50030 (1)
  • PROSITE:PS50089 (1)
  • PROSITE:PS51506 (1)
    		•
  • Pfam:PF02262 (1)
  • Pfam:PF02761 (1)
  • Pfam:PF02762 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cbl-001 (1) 4069
    Select Tool
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cbl No data available
    MARKER RELATIONSHIPS
    cblContained in: [BAC] DKEY-257C10 (1) (order this)
    cblEncodes: [EST] fd16a12
    [cDNA] MGC:92560 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007330 (1) 4023bp
    Select Tool
    Genomic GenBank:BX571886 (1) 178049bp
    Select Tool
    Polypeptide UniProtKB:F1QI90 (1) 913aa
    Select Tool
    Sequence Clusters UniGene:78552 (1)
    Sequence Information (all 14)
    OTHER cbl GENE PAGES
  • Alliance (1)
  • Gene:492364 (1)
  • VEGA:OTTDARG00000022950 (1)
  • Ensembl(GRCz11):ENSDARG00000009958 (2)
    • ORTHOLOGY for cbl (Chr: 15)
    CITATIONS (26)