Gene

cbl

ID

ZDB-GENE-041114-207

Name

Cbl proto-oncogene, E3 ubiquitin protein ligase

Symbol

cbl Nomenclature History

Previous Names

wu:fd16a12
zgc:92560 (1)

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Is predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of epidermal growth factor-activated receptor activity and signal transduction. Acts upstream of or within definitive hemopoiesis. Predicted to be located in cytoplasm. Used to study myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:92560 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Peng et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cbl Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
juvenile myelomonocytic leukemia	Alliance	?Juvenile myelomonocytic leukemia	607785
		Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	613563

Associated With cbl Via Experimental Models

Human Disease	Fish	Conditions	Citations
myeloproliferative neoplasm	cbl^rj32/rj32 (TU)	standard conditions	Peng et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR003153	Adaptor protein Cbl, N-terminal helical
Domain	IPR014741	Adaptor protein Cbl, EF hand-like
Domain	IPR014742	Adaptor protein Cbl, SH2-like domain
Domain	IPR015940	Ubiquitin-associated domain
Domain	IPR024159	Adaptor protein Cbl, PTB domain
Domain	IPR039520	E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass
Family	IPR024162	Adaptor protein Cbl
Homologous_superfamily	IPR009060	UBA-like superfamily
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036537	Adaptor protein Cbl, N-terminal domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily