ZFIN Gene: cbl

ZFIN ID: ZDB-GENE-041114-207

ZFIN ID: ZDB-GENE-041114-207

Gene Name:

Cbl proto-oncogene, E3 ubiquitin protein ligase

Gene Symbol:

cbl Nomenclature History

Previous Names:

wu:fd16a12, zgc:92560 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 15 Mapping Details/Browsers

Description:

Predicted to have SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in definitive hemopoiesis. Predicted to localize to membrane raft and plasma membrane. Used to study myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene).

Genome Resources:

Alliance (1), Gene:492364 (1), Ensembl(GRCz11):ENSDARG00000009958 (2)

GENE EXPRESSION
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:92560]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la012697Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
rj32	Point Mutation	Exon 8	Missense	ENU
sa15300	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35879	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42540	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-cbl		2
CRISPR2-cbl		2
CRISPR3-cbl		2
CRISPR4-cbl		2
CRISPR5-cbl		2
CRISPR6-cbl		2
CRISPR7-cbl		2
CRISPR8-cbl		2
CRISPR9-cbl		2
CRISPR10-cbl		2
MO1-cbl	N/A	1

PHENOTYPE

Data:	4 figures from Peng et al., 2015
Observed in:	basophilic erythroblast caudal hematopoietic tissue myeloid cell caudal hematopoietic tissue nucleate erythrocyte caudal hematopoietic tissue head kidney myeloid cell head kidney hematopoietic stem cell cell population proliferation myeloid cell cell population proliferation nucleate erythrocyte pronephros monocyte whole organism

DISEASE ASSOCIATED WITH cbl HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
juvenile myelomonocytic leukemia	Alliance	?Juvenile myelomonocytic leukemia	607785
		Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	613563

DISEASE ASSOCIATED WITH cbl VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
myeloproliferative neoplasm	cbl^rj32/rj32	standard conditions	Peng et al., 2015

GENE ONTOLOGY

Ontology	GO Term
Biological Process	definitive hemopoiesis (more)
Cellular Component	membrane raft (more)
Molecular Function	aspartyltransferase activity (more)

GO Terms (all 17)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	cbl-201 (1)	4069	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM cbl No data available

MARKER RELATIONSHIPS

cbl Contained in:	[BAC] DKEY-257C10 (1) (order this)
cbl Encodes:	[EST] fd16a12 [cDNA] MGC:92560 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001007330 (1)	4023 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571886 (1)	178049 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QI90 (1)	913 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 13)

ORTHOLOGY for cbl ( Chr: 15 )

CITATIONS (32)

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