ZFIN ID: ZDB-GENE-041114-207
Gene Name: Cbl proto-oncogene, E3 ubiquitin protein ligase
Gene Symbol: cbl    Nomenclature History

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Previous Names: wu:fd16a12, zgc:92560 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in definitive hemopoiesis. Predicted to localize to membrane raft and plasma membrane. Used to study myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene).
Genome Resources: Alliance (1),  Gene:492364 (1),  Ensembl(GRCz11):ENSDARG00000009958 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92560]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012697Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rj32 Point Mutation Exon 8 Missense ENU
    sa15300 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35879 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42540 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cbl
    2
    CRISPR2-cbl
    2
    CRISPR3-cbl
    2
    CRISPR4-cbl
    2
    CRISPR5-cbl
    2
    CRISPR6-cbl
    2
    CRISPR7-cbl
    2
    CRISPR8-cbl
    2
    CRISPR9-cbl
    2
    CRISPR10-cbl
    2
    MO1-cbl N/A 1
    DISEASE ASSOCIATED WITH cbl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    juvenile myelomonocytic leukemia Alliance ?Juvenile myelomonocytic leukemia 607785
    Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia 613563
    DISEASE ASSOCIATED WITH cbl VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    myeloproliferative neoplasm cblrj32/rj32 standard conditions Peng et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component membrane raft (more)
    Molecular Function aspartyltransferase activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cbl-201 (1)    Ensembl 4069
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cbl No data available
    MARKER RELATIONSHIPS
    cbl Contained in: [BAC] DKEY-257C10 (1) (order this)
    cbl Encodes: [EST] fd16a12
    [cDNA] MGC:92560 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007330 (1) 4023 nt
    Genomic GenBank:BX571886 (1) 178049 nt
    Select Tool
    Polypeptide UniProtKB:F1QI90 (1) 913 aa
    Sequence Information (all 13)
    ORTHOLOGY for cbl ( Chr: 15 )
    CITATIONS (32)