Gene

piezo1

ID
ZDB-GENE-041111-255
Name
piezo-type mechanosensitive ion channel component 1
Symbol
piezo1 Nomenclature History
Previous Names
  • FAM38A (1)
  • im:7149048
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits mechanosensitive ion channel activity and voltage-gated channel activity. Involved in several processes, including cell volume homeostasis; epidermal cell division; and regulation of epidermal cell division. Predicted to localize to endoplasmic reticulum and plasma membrane. Is expressed in nucleate erythrocyte and ventral mesoderm. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With piezo1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dehydrated hereditary stomatocytosis 1 Alliance Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema 194380
Lymphatic malformation 6 616843
Associated With piezo1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR031334 Piezo non-specific cation channel, R-Ras-binding domain
Domain IPR031805 Piezo domain
Family IPR027272 Piezo family
Domain Details Per Protein
Protein Length Piezo domain Piezo family Piezo non-specific cation channel, R-Ras-binding domain
UniProtKB:E7FD74 2436
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations