ZFIN ID: ZDB-GENE-041111-246
Gene Name: shroom family member 4
Gene Symbol: shroom4    Nomenclature History

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Previous Names: im:7145757, wu:fe05h01, zgc:194172, zgc:194173

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to localize to several cellular components, including the apical junction complex; apical plasma membrane; and cortical actin cytoskeleton. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human SHROOM4 (shroom family member 4).
Genome Resources: Alliance (1),  Gene:559035 (1),  Ensembl(GRCz11):ENSDARG00000079900 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7145757]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH shroom4 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Stocco dos Santos X-linked mental retardation syndrome 300434
DISEASE ASSOCIATED WITH shroom4 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process actin cytoskeleton organization (more)
Cellular Component adherens junction (more)
Molecular Function actin filament binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001478 PDZ domain
Domain IPR014799 Apx/Shrm Domain 2
Family IPR027685 Shroom family
Family IPR027687 Shroom4
Homologous_superfamily IPR036034 PDZ superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA shroom4-201 (1)    Ensembl 6362
shroom4-202 (1)    Ensembl 541
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM shroom4 No data available
MARKER RELATIONSHIPS
shroom4 Contained in: [BAC] CH211-69E13 (1), CH211-226L4 (1)
shroom4 Encodes: [EST] fe05h01, IMAGE:7145757 (1)
[cDNA] MGC:194172 (1), MGC:194173 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_005172333 (1) 6369 bp
Genomic GenBank:BX511061 (1) 200880 bp Blast at MegaBLAST
Polypeptide UniProtKB:F1Q6C1 (1) 1634 aa
Sequence Information (all 21)
ORTHOLOGY for shroom4 ( Chr: 7 )
CITATIONS (24)