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Gene

cox10

ID
ZDB-GENE-041111-239
Name
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
Symbol
cox10 Nomenclature History
Previous Names
  • im:7145568
  • im:7157205
  • wu:fb18a03
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable farnesyltranstransferase activity. Predicted to be involved in cellular respiration and heme biosynthetic process. Predicted to act upstream of or within heme O biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cox10 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mitochondrial complex IV deficiency, nuclear type 3 619046
Associated With cox10 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030470 UbiA prenyltransferase conserved site
Family IPR000537 UbiA prenyltransferase family
Family IPR006369 Protohaem IX farnesyltransferase
Family IPR016315 Protohaem IX farnesyltransferase, mitochondria
Domain Details Per Protein
Protein Length Protohaem IX farnesyltransferase Protohaem IX farnesyltransferase, mitochondria UbiA prenyltransferase conserved site UbiA prenyltransferase family
UniProtKB:Q566W2 452
UniProtKB:A4IG08 465
UniProtKB:A7MBQ6 470
UniProtKB:Q08C12 464
UniProtKB:Q29RE5 457
UniProtKB:F1QL30 447
UniProtKB:A0A2R8RZX3 305
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations