ZFIN ID: ZDB-GENE-041111-162
Gene Name: GLI family zinc finger 3
Gene Symbol: gli3    Nomenclature History

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Previous Name: im:7142603

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in regulation of neurogenesis. Predicted to localize to nucleus. Is expressed in several structures, including brain; ceratohyal cartilage; hindbrain neural tube; neural keel; and neural rod. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3).
Genome Resources: Alliance (1),  Gene:403042 (1),  Ensembl(GRCz11):ENSDARG00000052131 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2162 Point Mutation Unknown Unknown ENU
hu2965 Point Mutation Unknown Premature Stop ENU
hu2966 Point Mutation Unknown Unknown ENU
la011615Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014494Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014495Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8416 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8870 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25210 Point Mutation Unknown Premature Stop ENU
    sa32478 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37837 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37838 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gli3 N/A 6
    MO2-gli3 N/A 2
    MO3-gli3 N/A 1
    DISEASE ASSOCIATED WITH gli3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Greig cephalopolysyndactyly syndrome Alliance Greig cephalopolysyndactyly syndrome 175700
    Pallister-Hall syndrome Alliance Pallister-Hall syndrome 146510
    polydactyly Alliance Polydactyly, postaxial, types A1 and B 174200
    Polydactyly, preaxial, type IV 174700
    {Hypothalamic hamartomas, somatic} 241800
    DISEASE ASSOCIATED WITH gli3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process generation of neurons (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gli3-201 (1)    Ensembl 6688
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gli3 No data available
    MARKER RELATIONSHIPS
    gli3 Contained in: [BAC] CH73-105F15 (1), CH211-281G2 (1), DKEY-90P8 (1) (order this), DKEY-149L16 (1) (order this)
    [Fosmid] CH1073-45O15 (1), CH1073-328K10 (1)
    gli3 Encodes: [EST] IMAGE:7142603 (1)
    [cDNA] MGC:194808 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_205728 (1) 5086 nt
    Genomic GenBank:BX005153 (1) 177146 nt
    Select Tool
    Polypeptide UniProtKB:F1QSH8 (1) 1553 aa
    Sequence Information (all 25)
    ORTHOLOGY for gli3 ( Chr: 24 )
    CITATIONS (53)