Gene

gli3

ID
ZDB-GENE-041111-162
Name
GLI family zinc finger 3
Symbol
gli3 Nomenclature History
Previous Names
  • im:7142603
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of neurogenesis. Located in chromatin. Is expressed in several structures, including brain; ceratohyal cartilage; hindbrain neural tube; neural keel; and neural rod. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Devine et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gli3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Greig cephalopolysyndactyly syndrome Alliance Greig cephalopolysyndactyly syndrome 175700
Pallister-Hall syndrome Alliance Pallister-Hall syndrome 146510
polydactyly Alliance Polydactyly, postaxial, types A1 and B 174200
polydactyly Alliance Polydactyly, preaxial, type IV 174700
Associated With gli3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Family IPR032851 Transcription factor GLI3
Family IPR043359 C2H2-type zinc-finger protein GLI-like
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length C2H2-type zinc-finger protein GLI-like Transcription factor GLI3 Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:F1QSH8 1553
UniProtKB:Q6U6Z9 1553
UniProtKB:B3DK55 1552
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations