Gene

gli3

ID

ZDB-GENE-041111-162

Name

GLI family zinc finger 3

Symbol

gli3 Nomenclature History

Previous Names

fpr (1)
im:7142603

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in regulation of neurogenesis. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Is expressed in several structures, including brain; ceratohyal cartilage; hindbrain neural tube; neural keel; and neural rod. Orthologous to human GLI3 (GLI family zinc finger 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7142603 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Devine et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gli3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Greig cephalopolysyndactyly syndrome	Alliance	Greig cephalopolysyndactyly syndrome	175700
Pallister-Hall syndrome	Alliance	Pallister-Hall syndrome	146510
polydactyly	Alliance	Polydactyly, postaxial, types A1 and B	174200
polydactyly	Alliance	Polydactyly, preaxial, type IV	174700