ZFIN ID: ZDB-GENE-041027-1
Gene Name: mitogen-activated protein kinase kinase 2a
Gene Symbol: map2k2a    Nomenclature History

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Previous Names: map2k2, mek2 (1), fa56c06, wu:fa56c06, zgc:123171 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have MAP kinase kinase activity and protein serine/threonine kinase activity. Predicted to be involved in activation of MAPK activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome and small intestine adenocarcinoma. Is expressed in cardiac ventricle. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2).
Genome Resources: Alliance (1),  Gene:563181 (1),  Ensembl(GRCz11):ENSDARG00000006609 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu1108]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1721 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa3186 Point Mutation Unknown Premature Stop ENU
    sa37498 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH map2k2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cardiofaciocutaneous syndrome 4 Alliance Cardiofaciocutaneous syndrome 4 615280
    DISEASE ASSOCIATED WITH map2k2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA map2k2a-201 (1)    Ensembl 3193
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM map2k2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(cyt1:map2k2a_S219D-GFP) cyt1 GFPmap2k2a Danio rerio 1 1
    MARKER RELATIONSHIPS
    map2k2a Contained in: [BAC] CH211-195M2 (1)
    map2k2a Encodes: [EST] eu1108 (1), fa56c06
    [cDNA] MGC:123171 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001037391 (1) 1435 nt
    Genomic GenBank:BX088720 (1) 190269 nt
    Select Tool
    Polypeptide UniProtKB:Q1LY62 (1) 397 aa
    Sequence Information (all 18)
    ORTHOLOGY for map2k2a ( Chr: 22 )
    CITATIONS (36)