Gene

nbas

ID

ZDB-GENE-041014-367

Name

NBAS subunit of NRZ tethering complex

Symbol

nbas Nomenclature History

Previous Names

si:ch211-214k9.1 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable SNARE binding activity. Involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and nuclear-transcribed mRNA catabolic process. Acts upstream of or within embryonic viscerocranium morphogenesis and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human NBAS (NBAS subunit of NRZ tethering complex).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nbas Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Infantile liver failure syndrome 2	616483
		Short stature, optic nerve atrophy, and Pelger-Huet anomaly	614800

Associated With nbas Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013244	Sec39 domain
Domain	IPR029145	Neuroblastoma-amplified sequence, N-terminal
Domain	IPR054751	NBAS subunit of NRZ tethering complex, C-terminal
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat