ZFIN ID: ZDB-GENE-041014-328
Gene Name: activating transcription factor 6
Gene Symbol: atf6    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: fi12h10, si:ch211-199m3.9, si:ch211-260g14.1, wu:fi12h10

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and cAMP response element binding activity. Involved in endoplasmic reticulum unfolded protein response and response to hypoxia. Predicted to localize to endoplasmic reticulum membrane and nucleus. Is expressed in brain; head; liver; and trunk. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6).
Genome Resources: Alliance (1),  Gene:558071 (1),  Ensembl(GRCz11):ENSDARG00000012656 (2)
GENE EXPRESSION
All Expression Data: 20 figures from 18 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028256Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1154 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23750 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37084 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37085 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43484 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-atf6 N/A 2
    MO2-atf6 N/A 2
    DISEASE ASSOCIATED WITH atf6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    achromatopsia 7 Alliance Achromatopsia 7 616517
    DISEASE ASSOCIATED WITH atf6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to hypoxia (more)
    Cellular Component endoplasmic reticulum membrane (more)
    Molecular Function cAMP response element binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atf6-201 (1)    Ensembl 4192
    atf6-202 (1)    Ensembl 937
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atf6
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(fabp10a:atf6-mCherry,myl7:EGFP) fabp10amyl7 atf6EGFPmCherry Danio rerio 2 2
    MARKER RELATIONSHIPS
    atf6 Contained in: [BAC] CH211-199M3 (1), CH211-260G14 (1)
    atf6 Encodes: [EST] fi12h10
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001110519 (1) 1962 nt
    Genomic GenBank:BX571790 (1) 200944 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5RH85 (1) 653 aa
    Sequence Information (all 10)
    ORTHOLOGY for atf6 ( Chr: 20 )
    CITATIONS (71)