ZFIN Gene: atf6

ZFIN ID: ZDB-GENE-041014-328

ZFIN ID: ZDB-GENE-041014-328

Gene Name:

activating transcription factor 6

Gene Symbol:

atf6 Nomenclature History

Previous Names:

fi12h10, si:ch211-199m3.9, si:ch211-260g14.1, wu:fi12h10

Gene Type:

protein_coding_gene

Location:

Chr: 20 Mapping Details/Browsers

Description:

Predicted to have DNA-binding transcription factor activity and cAMP response element binding activity. Involved in endoplasmic reticulum unfolded protein response and response to hypoxia. Predicted to localize to endoplasmic reticulum membrane and nucleus. Is expressed in brain; head; liver; and trunk. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6).

Genome Resources:

Alliance (1), Gene:558071 (1), Ensembl(GRCz11):ENSDARG00000012656 (2)

GENE EXPRESSION
All Expression Data:	20 figures from 18 publications
Wild-type Stages, Structures:	Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
	brain head liver trunk whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la028256Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa1154	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa23750	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37084	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37085	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43484	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-atf6	N/A	2
MO2-atf6	N/A	2

PHENOTYPE

Data:	Fig. 6 from Cinaroglu et al., 2011
Observed in:	endoplasmic reticulum unfolded protein response

DISEASE ASSOCIATED WITH atf6 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
achromatopsia 7	Alliance	Achromatopsia 7	616517

DISEASE ASSOCIATED WITH atf6 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	response to hypoxia (more)
Cellular Component	endoplasmic reticulum membrane (more)
Molecular Function	cAMP response element binding (more)

GO Terms (all 8)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	atf6-201 (1)	4192	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	atf6-202 (1)	937	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM atf6

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(fabp10a:atf6-mCherry,myl7:EGFP)	fabp10a, myl7	atf6, EGFP, mCherry	Danio rerio	2	2

MARKER RELATIONSHIPS

atf6 Contained in:	[BAC] CH211-199M3 (1), CH211-260G14 (1)
atf6 Encodes:	[EST] fi12h10

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001110519 (1)	1962 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571790 (1)	200944 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:Q5RH85 (1)	653 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 10)

ORTHOLOGY for atf6 ( Chr: 20 )

CITATIONS (71)

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