ZFIN ID: ZDB-GENE-041014-323
Gene Name: prostaglandin-endoperoxide synthase 2b
Gene Symbol: ptgs2b    Nomenclature History

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Previous Names: Cox-2b (1), si:dkey-97o5.6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits peroxidase activity. Involved in cellular response to organic cyclic compound. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; arthritis (multiple); cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Is expressed in several structures, including gonad; gut; heart; kidney; and nervous system. Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2).
Genome Resources: Alliance (1),  Gene:559020 (1),  Ensembl(GRCz11):ENSDARG00000010276 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13114 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23755 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29400 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ptgs2b
    1
    MO1-ptgs2b N/A 4
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ptgs2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ptgs2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to organic cyclic compound (more)
    Molecular Function peroxidase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000742 EGF-like domain
    Homologous_superfamily IPR010255 Haem peroxidase superfamily
    Family IPR019791 Haem peroxidase, animal-type
    Family IPR029576 Prostaglandin G/H synthase 2
    Homologous_superfamily IPR037120 Haem peroxidase domain superfamily, animal type
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ptgs2b-201 (1)    Ensembl 2556
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptgs2b No data available
    MARKER RELATIONSHIPS
    ptgs2b Contained in: [BAC] DKEY-97O5 (1) (order this)
    ptgs2b Encodes: [cDNA] MGC:162338 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001025504 (1) 2534 bp
    Genomic GenBank:BX323056 (1) 134072 bp
    Select Tool
    Polypeptide UniProtKB:Q5RI06 (1) 606 aa
    Sequence Information (all 12)
    ORTHOLOGY for ptgs2b ( Chr: 20 )
    CITATIONS (70)