ZFIN ID: ZDB-GENE-041014-209
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Gene Name: meprin A, beta
Gene Symbol: mep1b    Nomenclature History

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Previous Names: si:ch211-191a24.6 (1), zgc:153272 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to the meprin A complex. Is expressed in several structures, including epidermis; gill; heart; liver; and pleuroperitoneal region. Orthologous to human MEP1B (meprin A subunit beta).
Genome Resources: Alliance (1),  Gene:100151009 (1),  Ensembl(GRCz11):ENSDARG00000037533 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021772Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mep1b N/A 1
    PHENOTYPE
    Data: 2 figures from Schütte et al., 2010
    Observed in:
    DISEASE ASSOCIATED WITH mep1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mep1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000998 MAM domain
    Domain IPR001506 Peptidase M12A
    Domain IPR002083 MATH/TRAF domain
    Domain IPR006026 Peptidase, metallopeptidase
    Domain IPR034038 Meprin peptidase domain
    Family IPR008294 Meprin alpha/beta subunit
    Homologous_superfamily IPR008974 TRAF-like
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mep1b-201 (1)    Ensembl 2320
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mep1b polyclonal IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mep1b No data available
    MARKER RELATIONSHIPS
    mep1b Contained in: [BAC] CH211-39I19 (1), CH211-191A24 (1)
    mep1b Encodes: [cDNA] MGC:153272 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001076621 (1) 2320 nt
    Select Tool
    Genomic GenBank:CT583652 (1) 171652 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QQY7 (1) 707 aa
    Select Tool
    Sequence Information (all 12)
    ORTHOLOGY for mep1b ( Chr: 20 )
    CITATIONS (26)