ZFIN ID: ZDB-GENE-041010-76
Gene Name: cathepsin L, like
Gene Symbol: ctsll    Nomenclature History

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Previous Names: ctsl (1), zgc:101557

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to localize to the extracellular space and lysosome. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L) and CTSV (cathepsin V).
Genome Resources: Alliance (1),  Gene:449826 (1),  Ensembl(GRCz11):ENSDARG00000011701 (1)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ctsll HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH ctsll VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process proteolysis (more)
Cellular Component extracellular space (more)
Molecular Function cysteine-type peptidase activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Domain IPR000668 Peptidase C1A, papain C-terminal
Domain IPR013201 Cathepsin propeptide inhibitor domain (I29)
Active_site IPR025660 Cysteine peptidase, histidine active site
Active_site IPR025661 Cysteine peptidase, asparagine active site
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain IPR039417 Papain-like cysteine endopeptidase
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ctsll-201 (1)    Ensembl 1424
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ctsll No data available
MARKER RELATIONSHIPS
ctsll Contained in: [BAC] CH211-137I24 (1)
ctsll Encodes: [cDNA] MGC:101557 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001005999 (1) 1437 bp
Genomic GenBank:BX119902 (1) 170241 bp
Select Tool
Polypeptide UniProtKB:A2BEM8 (1) 337 aa
Sequence Information (all 13)
ORTHOLOGY for ctsll ( Chr: 5 )
CITATIONS (18)