Gene

sirt4

ID
ZDB-GENE-041010-65
Name
sirtuin 4
Symbol
sirt4 Nomenclature History
Previous Names
  • im:7139453
  • zgc:103539 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have several functions, including NAD+ binding activity; NAD-dependent protein deacetylase activity; and zinc ion binding activity. Predicted to be involved in protein ADP-ribosylation. Predicted to localize to mitochondrial matrix. Is expressed in liver and retina. Orthologous to human SIRT4 (sirtuin 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sirt4 Human Ortholog
No data available
Associated With sirt4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR026590 Sirtuin family, catalytic core domain
Family IPR003000 Sirtuin family
Family IPR026587 Sirtuin, class II
Homologous_superfamily IPR026591 Sirtuin, catalytic core small domain superfamily
Homologous_superfamily IPR029035 DHS-like NAD/FAD-binding domain superfamily
Domain Details Per Protein
Protein Length DHS-like NAD/FAD-binding domain superfamily Sirtuin, catalytic core small domain superfamily Sirtuin, class II Sirtuin family Sirtuin family, catalytic core domain
UniProtKB:F1QHM6 310
UniProtKB:Q5XJ86 310
UniProtKB:X1WCG8 273
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-sirt4 polyclonal IgG Goat
  • WB
Abcam plc
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations