ZFIN ID: ZDB-GENE-041010-5
Gene Name: parkinson protein 7
Gene Symbol: park7    Nomenclature History

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Previous Names: DJ-1 (1), zDJ-1 (1), zgc:103725

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have several functions, including hydro-lyase activity; peptidase activity; and protein homodimerization activity. Involved in response to oxidative stress. Predicted to localize to cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; male organism; musculature system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase).
Genome Resources: Alliance (1),  Gene:449674 (1),  Ensembl(GRCz11):ENSDARG00000116835 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ub2000 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-park7 1
MO1-park7 N/A 1
MO2-park7 N/A 1
MO3-park7 N/A 1
MO4-park7 N/A 1
MO5-park7 N/A 1
PHENOTYPE
Data: Fig. 3 from Baulac et al., 2009
Observed in:
DISEASE ASSOCIATED WITH park7 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 7 Alliance Parkinson disease 7, autosomal recessive early-onset 606324
DISEASE ASSOCIATED WITH park7 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to oxidative stress (more)
Cellular Component mitochondrion (more)
Molecular Function glyoxalase (glycolic acid-forming) activity (more)
GO Terms (all 36)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-park7 monoclonal IgM Mouse WB Abcam plc
4
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM park7
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(gfap:EGFP-2A-FLAG-park7) gfap 2AEGFPFLAGpark7 Danio rerio 1 1
MARKER RELATIONSHIPS
park7 Contained in: [BAC] DKEYP-123H11 (1)
park7 Encodes: [cDNA] MGC:103725 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001005938 (1) 959 nt
Genomic GenBank:BX571706 (1) 196333 nt
Select Tool
Polypeptide UniProtKB:Q5XJ36 (1) 189 aa
Sequence Information (all 11)
ORTHOLOGY for park7 ( Chr: 11 )
CITATIONS (38)