Gene

park7

ID

ZDB-GENE-041010-5

Name

parkinson protein 7

Symbol

park7 Nomenclature History

Previous Names

DJ-1 (1)
zDJ-1 (1)
zgc:103725

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Is predicted to enable several functions, including hydro-lyase activity; peptidase activity; and protein homodimerization activity. Involved in several processes, including cellular protein modification process; guanine deglycation; and positive regulation of oxidative phosphorylation uncoupler activity. Acts upstream of or within response to oxidative stress. Predicted to be located in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; male organism; musculature system; and nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

26 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:103725 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With park7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Parkinson's disease 7	Alliance	Parkinson disease 7, autosomal recessive early-onset	606324

Associated With park7 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Parkinson's disease	park7^{ub2000/ub2000}	standard conditions	Edson et al., 2019
retinal degeneration	park7^{ub2000/ub2000}	standard conditions	Gharbi et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002818	DJ-1/PfpI
Family	IPR006287	Protein/nucleic acid deglycase DJ-1
Homologous_superfamily	IPR029062	Class I glutamine amidotransferase-like

Domain Details Per Protein

Protein	Length	Class I glutamine amidotransferase-like	DJ-1/PfpI	Protein/nucleic acid deglycase DJ-1
UniProtKB:Q5XJ36 InterPro	189

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-park7	polyclonal	park7	IgG	Rabbit	WB	Novus Biologicals, LLC	4
Ab1-park7	monoclonal	park7	IgM	Mouse	WB	Abcam plc	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations