Gene

park7

ID
ZDB-GENE-041010-5
Name
parkinson protein 7
Symbol
park7 Nomenclature History
Previous Names
  • DJ-1 (1)
  • zDJ-1 (1)
  • zgc:103725
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have several functions, including peptidase activity; protein deglycase activity; and protein homodimerization activity. Involved in response to oxidative stress. Predicted to localize to cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; cerebral infarction; and middle cerebral artery infarction. Is expressed in several structures, including alar plate midbrain region; digestive system; male organism; musculature system; and nervous system. Orthologous to human PARK7 (Parkinsonism associated deglycase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With park7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 7 Alliance Parkinson disease 7, autosomal recessive early-onset 606324
Associated With park7 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002818 DJ-1/PfpI
Family IPR006287 Protein/nucleic acid deglycase DJ-1
Homologous_superfamily IPR029062 Class I glutamine amidotransferase-like
Domain Details Per Protein
Protein Length Class I glutamine amidotransferase-like DJ-1/PfpI Protein/nucleic acid deglycase DJ-1
UniProtKB:Q5XJ36 189
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-park7 polyclonal IgG Rabbit
  • WB
Novus Biologicals, LLC
3
Ab1-park7 monoclonal IgM Mouse
  • WB
Abcam plc
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations