Gene

cradd

ID
ZDB-GENE-041010-168
Name
CASP2 and RIPK1 domain containing adaptor with death domain
Symbol
cradd Nomenclature History
Previous Names
  • zgc:101717
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have death domain binding activity and protease binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity. Predicted to localize to CBM complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cradd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive non-syndromic intellectual disability Alliance Mental retardation, autosomal recessive 34, with variant lissencephaly 614499
Associated With cradd Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000488 Death domain
Domain IPR001315 CARD domain
Domain IPR037926 CRADD, Death domain
Domain IPR042148 RAIDD, CARD domain
Family IPR037939 Death domain-containing protein CRADD
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length CARD domain CRADD, Death domain Death domain Death domain-containing protein CRADD Death-like domain superfamily RAIDD, CARD domain
UniProtKB:Q5XJP2 200
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations