Gene

mep1a.1

ID
ZDB-GENE-041001-209
Name
meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1
Symbol
mep1a.1 Nomenclature History
Previous Names
  • MEP1Aa (1)
  • si:dkey-30j22.7 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to integral component of membrane. Is expressed in several structures, including brush border epithelial cell; digestive system; epidermis; gill; and heart. Orthologous to human MEP1A (meprin A subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Schütte et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mep1a.1 Human Ortholog
No data available
Associated With mep1a.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000998 MAM domain
Domain IPR001506 Peptidase M12A
Domain IPR002083 MATH/TRAF domain
Domain IPR006026 Peptidase, metallopeptidase
Homologous_superfamily IPR008974 TRAF-like
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily MAM domain MATH/TRAF domain Metallopeptidase, catalytic domain superfamily Peptidase M12A Peptidase, metallopeptidase TRAF-like
UniProtKB:Q5RHM1 598
UniProtKB:Q5RKM1 594
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mep1a.1 polyclonal
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
This gene and mep1a.2 (ZDB-GENE-041001-208) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human MEP1A and mouse Mep1a based on amino acid identity and conserved location.
Citations