ZFIN ID: ZDB-GENE-041001-209
Gene Name: meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1
Gene Symbol: mep1a.1    Nomenclature History

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Previous Names: MEP1Aa (1), si:dkey-30j22.7 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to membrane. Is expressed in several structures, including brush border epithelial cell; digestive system; epidermis; gill; and heart. Orthologous to human MEP1A (meprin A subunit alpha).
Genome Resources: Alliance (1),  Gene:553530 (1),  Ensembl(GRCz11):ENSDARG00000029747 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021600Tg Transgenic Insertion Unknown Unknown DNA
sa6643 Point Mutation Unknown Premature Stop ENU
sa10535 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13188 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17730 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31046 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43495 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mep1a.1 N/A 1
    PHENOTYPE
    Data: Fig. 2 from Schütte et al., 2010
    Observed in:
    DISEASE ASSOCIATED WITH mep1a.1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mep1a.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component membrane (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mep1a.1-201 (1)    Ensembl 1983
    ncRNA mep1a.1-002 (1)    Ensembl 664
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mep1a.1 polyclonal IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mep1a.1 No data available
    MARKER RELATIONSHIPS
    mep1a.1 Contained in: [BAC] DKEY-30J22 (1) (order this)
    mep1a.1 Encodes: [cDNA] MGC:136668 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001030281 (1) 2005 nt
    Genomic GenBank:BX510920 (1) 220240 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5RHM1 (1) 598 aa
    Sequence Information (all 13)
    ORTHOLOGY for mep1a.1 ( Chr: 20 )
    CITATIONS (29)