Gene

ncoa1

ID
ZDB-GENE-041001-175
Name
nuclear receptor coactivator 1
Symbol
ncoa1 Nomenclature History
Previous Names
  • DKEY-34F16.7 (1)
  • si:dkey-34f16.6
  • si:dkey-5g7.1
  • si:dkey-5g7.6
  • SRC1 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in cellular response to hormone stimulus and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in axis; central nervous system; intestinal bulb; liver; and presumptive diencephalon. Orthologous to human NCOA1 (nuclear receptor coactivator 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Manesia et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ncoa1 Human Ortholog
No data available
Associated With ncoa1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000014 PAS domain
Domain IPR010011 Domain of unknown function DUF1518
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR013767 PAS fold
Domain IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
Domain IPR014935 Nuclear receptor coactivator, receptor-binding domain
Family IPR017426 Nuclear receptor coactivator
Family IPR028819 Nuclear receptor coactivator 1
Homologous_superfamily IPR009110 Nuclear receptor coactivator, interlocking
Homologous_superfamily IPR035965 PAS domain superfamily
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Homologous_superfamily IPR037077 Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily
Domain Details Per Protein
Protein Length Domain of unknown function DUF1518 Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Nuclear receptor coactivator Nuclear receptor coactivator 1 Nuclear receptor coactivator, interlocking Nuclear receptor coactivator, Ncoa-type, interlocking Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily Nuclear receptor coactivator, receptor-binding domain PAS domain PAS domain superfamily PAS fold
UniProtKB:Q1L662 177
UniProtKB:Q5RIG3 1349
UniProtKB:A0A2R9YJM7 1339
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations