ZFIN Gene: rbfox1

ZFIN ID: ZDB-GENE-040927-11

ZFIN ID: ZDB-GENE-040927-11

Gene Name:

RNA binding fox-1 homolog 1

Gene Symbol:

rbfox1

Sequence Ontology ID :

SO:0000704

Previous Names:

a2bp1, zgc:103635 (1)

Location:

Chr: 3 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have mRNA binding activity. Involved in heart contraction; hypothalamus development; and regulation of alternative mRNA splicing, via spliceosome. Predicted to localize to the cytoplasm ...

GENE EXPRESSION
All Expression Data:	9 figures from 3 publications
Directly Submitted Expression Data:	7 figures (9 images) from Thisse et al., 2004 [MGC:103635]
Wild-type Stages, Structures:	Segmentation:10-13 somites (14.0h-16.0h) to Adult (90d-730d, breeding adult)
	brain cranial ganglion eye heart hindbrain intestine liver midbrain neural keel neuron retinal ganglion cell layer skeletal muscle spinal cord whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa15281	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa15940	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa26072	Point Mutation	Unknown	Premature Stop	ENU
sa38393	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	5 figures from 2 publications
Observed in:	atrium blood circulation brain cardiac ventricle heart alternative mRNA splicing, via spliceosome heart hypothalamus development regulation of RNA splicing

DISEASE ASSOCIATED WITH rbfox1 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH rbfox1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	heart contraction (more)
Cellular Component	cytoplasm (more)
Molecular Function	nucleic acid binding (more)

GO Terms (all 12)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000504 (1) InterPro:IPR012677 (1) InterPro:IPR017325 (1) InterPro:IPR025670 (1) InterPro:IPR034237 (1) InterPro:IPR035979 (1)	PROSITE:PS50102 (1)	Pfam:PF00076 (1) Pfam:PF12414 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	rbfox1-002 (1)	662	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	rbfox1-202 (1)	3190	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	rbfox1-203 (1)	944	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	rbfox1-204 (1)	759	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	rbfox1-205 (1)	774	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	rbfox1-206 (1)	865	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM rbfox1 No data available

MARKER RELATIONSHIPS

rbfox1Contained in:	[BAC] CH211-234D12 (1) (order this), DKEY-13A11 (1) (order this), DKEY-23A11 (1) (order this), DKEY-41B16 (1) (order this), DKEY-230M3 (1) (order this)
rbfox1Encodes:	[cDNA] MGC:103635 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001005596 (1)	1177bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR792426 (1)	210874bp	Blast at MegaBLAST
Polypeptide	UniProtKB:Q642J5 (1)	373aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:133079 (1)

Sequence Information (all 52)

OTHER rbfox1 GENE PAGES

Alliance (1)

Gene:449554 (1)

VEGA:OTTDARG00000021708 (1)

Ensembl(GRCz11):ENSDARG00000014746 (2)

ORTHOLOGY for rbfox1 (Chr: 3)

CITATIONS (28)

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