Gene
grid2
- ID
- ZDB-GENE-040913-1
- Name
- glutamate receptor, ionotropic, delta 2
- Symbol
- grid2 Nomenclature History
- Previous Names
-
- glurd2 (1)
- si:rp71-1l7.1
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have ionotropic glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission; ionotropic glutamate receptor signaling pathway; and modulation of chemical synaptic transmission. Predicted to localize to integral component of plasma membrane and postsynaptic density membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Is expressed in brain and eye. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 18 | Alliance | Spinocerebellar ataxia, autosomal recessive 18 | 616204 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
| Protein | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q68Y21
|
1009 | ||||||
|
UniProtKB:A0A8M2BEL3
|
927 | ||||||
|
UniProtKB:A0A8M3B4Y9
|
876 |
Interactions and Pathways
No data available
Plasmids
No data available