ZFIN ID: ZDB-GENE-040912-164
Gene Name: general transcription factor IIH, polypeptide 1
Gene Symbol: gtf2h1    Nomenclature History

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Previous Names: p62 (1), zgc:92126, zmp:0000000569 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to contribute to DNA-dependent ATPase activity and RNA polymerase II CTD heptapeptide repeat kinase activity. Predicted to be involved in phosphorylation of RNA polymerase II C-terminal domain; transcription by RNA polymerase I; and transcription by RNA polymerase II. Predicted to localize to the transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Orthologous to human GTF2H1 (general transcription factor IIH subunit 1).
Genome Resources: Alliance (1),  Gene:447857 (1),  Ensembl(GRCz11):ENSDARG00000026701 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92126]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6789 Point Mutation Unknown Splice Site ENU
sa10259 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13977 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37983 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gtf2h1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gtf2h1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process nucleotide-excision repair (more)
    Cellular Component transcription factor TFIIH core complex (more)
    Molecular Function CONTRIBUTES_TO   DNA-dependent ATPase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR005607 BSD domain
    Domain IPR013876 TFIIH p62 subunit, N-terminal
    Family IPR027079 TFIIH subunit Tfb1/GTF2H1
    Homologous_superfamily IPR011993 PH-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gtf2h1-201 (1)    Ensembl 2461
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gtf2h1 No data available
    MARKER RELATIONSHIPS
    gtf2h1 Contained in: [BAC] CH73-340G20 (1), CH211-112D9 (1)
    gtf2h1 Encodes: [cDNA] MGC:92126 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004596 (1) 2493 nt
    Genomic GenBank:CU184832 (1) 187294 nt
    Select Tool
    Polypeptide UniProtKB:Q66I03 (1) 550 aa
    Sequence Information (all 10)
    ORTHOLOGY for gtf2h1 ( Chr: 25 )
    CITATIONS (21)