Gene

bmpr1ab

ID
ZDB-GENE-040912-150
Name
bone morphogenetic protein receptor, type IAb
Symbol
bmpr1ab Nomenclature History
Previous Names
  • alk3b (1)
  • wu:fe05b06
  • wu:fe06e10
  • zgc:92227
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have SMAD binding activity and transforming growth factor beta receptor activity, type I. Involved in BMP signaling pathway; circulatory system development; and regionalization. Predicted to localize to plasma membrane and receptor complex. Is expressed in several structures, including blastoderm; blastodisc; cardinal system; margin; and ovarian follicle. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A).
Genome Resources
Note
None
Expression
All Expression Data
9 figures from 8 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. S3 from Little et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmpr1ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary mixed polyposis syndrome 2 Alliance Polyposis syndrome, hereditary mixed, 2 610069
juvenile polyposis syndrome Alliance Juvenile polyposis syndrome, infantile form 174900
juvenile polyposis syndrome Alliance Polyposis, juvenile intestinal 174900
Associated With bmpr1ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000472 Activin types I and II receptor domain
Domain IPR000719 Protein kinase domain
Domain IPR003605 GS domain
Family IPR000333 Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Activin types I and II receptor domain GS domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Ser/Thr protein kinase, TGFB receptor
UniProtKB:Q66HY1 534
UniProtKB:A0A0R4IZG7 535
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations