ZFIN ID: ZDB-GENE-040912-150
Gene Name: bone morphogenetic protein receptor, type IAb
Gene Symbol: bmpr1ab    Nomenclature History

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Previous Names: alk3b (1), wu:fe05b06, wu:fe06e10, zgc:92227

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have SMAD binding activity; growth factor binding activity; and transforming growth factor beta receptor activity, type I. Involved in BMP signaling pathway; circulatory system development; and regionalization. Predicted to localize to the integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in intestinal disease and juvenile polyposis syndrome. Is expressed in blastoderm; blastodisc; head; neural tube; and ovarian follicle. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A).
Genome Resources: Alliance (1),  Gene:447846 (1),  Ensembl(GRCz11):ENSDARG00000105045 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012165Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018163Tg Transgenic Insertion Unknown Unknown DNA
    la018164Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018166Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018167Tg Transgenic Insertion Unknown Unknown DNA
    sa28 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16062 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22103 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bmpr1ab N/A 3
    MO2-bmpr1ab N/A 5
    PHENOTYPE
    Data: Fig. S3 from Little et al., 2009
    Observed in:
    DISEASE ASSOCIATED WITH bmpr1ab HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary mixed polyposis syndrome 2 Alliance Polyposis syndrome, hereditary mixed, 2 610069
    juvenile polyposis syndrome Alliance Juvenile polyposis syndrome, infantile form 174900
    Polyposis, juvenile intestinal 174900
    DISEASE ASSOCIATED WITH bmpr1ab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process BMP signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000333 Ser/Thr protein kinase, TGFB receptor
    Domain IPR000472 Activin types I and II receptor domain
    Domain IPR000719 Protein kinase domain
    Domain IPR003605 GS domain
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Binding_site IPR017441 Protein kinase, ATP binding site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bmpr1ab-201 (1)    Ensembl 3258
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bmpr1ab No data available
    MARKER RELATIONSHIPS
    bmpr1ab Contained in: [BAC] CH211-103O20 (1), CH211-135B5 (1)
    bmpr1ab Encodes: [EST] fe05b06 (1), fe06e10 (1)
    [cDNA] MGC:92227 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001004585 (1) 3277 bp
    Genomic GenBank:CR847541 (1) 178133 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IZG7 (1) 535 aa
    Sequence Information (all 14)
    ORTHOLOGY for bmpr1ab ( Chr: 12 )
    CITATIONS (45)