ZFIN ID: ZDB-GENE-040912-117
Gene Name: LY6/PLAUR domain containing 6
Gene Symbol: lypd6    Nomenclature History

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Previous Name: zgc:101899 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have acetylcholine receptor inhibitor activity. Involved in Spemann organizer formation and regulation of Wnt signaling pathway. Localizes to anchored component of plasma membrane. Is expressed in several structures, including DEL; hypoblast; margin; nervous system; and optic vesicle. Orthologous to human LYPD6 (LY6/PLAUR domain containing 6).
Genome Resources: Alliance (1),  Gene:447932 (1),  Ensembl(GRCz11):ENSDARG00000004307 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 2 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [IMAGE:6897270]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026820Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lypd6 N/A 1
    PHENOTYPE
    Data: Fig. 2 from Özhan et al., 2013
    Observed in:
    DISEASE ASSOCIATED WITH lypd6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lypd6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of canonical Wnt signaling pathway (more)
    Cellular Component anchored component of plasma membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lypd6-201 (1)    Ensembl 1237
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lypd6 No data available
    MARKER RELATIONSHIPS
    lypd6 Contained in: [BAC] DKEY-91I10 (1) (order this)
    lypd6 Encodes: [EST] IMAGE:6897270 (1)
    [cDNA] MGC:101899 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004670 (1) 847 nt
    Genomic GenBank:CR394542 (1) 193811 nt
    Select Tool
    Polypeptide UniProtKB:Q66IA6 (1) 174 aa
    Sequence Information (all 12)
    ORTHOLOGY for lypd6 ( Chr: 9 )
    CITATIONS (28)