Gene
nhsl1b
- ID
- ZDB-GENE-040910-1
- Name
- NHS-like 1b
- Symbol
- nhsl1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Acts upstream of or within motor neuron migration. Located in membrane. Is expressed in branchiomotor neurons; central nervous system; facial nerve motor nucleus; somite; and trigeminal motor nucleus. Orthologous to human NHSL1 (NHS like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Walsh et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh131 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| fh280 | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh281 | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh353 | Allele with one point mutation | Unknown | Unknown | ENU | |
| la013853Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021540Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nhsl1b_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa32298 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43469 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43470 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-nhsl1b | N/A | Walsh et al., 2011 |
| MO2-nhsl1b | N/A | Walsh et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR024845 | Actin remodeling regulator NHS-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Actin remodeling regulator NHS-like |
|---|---|---|---|
| UniProtKB:A0A8M2B7Q2 | InterPro | 1562 | |
| UniProtKB:A0A8M2B7N1 | InterPro | 1579 | |
| UniProtKB:A0A8M3AKZ2 | InterPro | 1518 | |
| UniProtKB:E7EXR7 | InterPro | 1606 | |
| UniProtKB:A0A8M2B7Q5 | InterPro | 1537 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nhsl1b-201
(1)
|
Ensembl | 4,821 nt | ||
| mRNA |
nhsl1b-202
(1)
|
Ensembl | 6,384 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-nhsl1b | polyclonal | Rabbit |
|
AnaSpec
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195E3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005160766 (1) | 7683 nt | ||
| Genomic | GenBank:AL929182 | 225515 nt | ||
| Polypeptide | UniProtKB:E7EXR7 (1) | 1606 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nelson, A.C., Cutty, S.J., Niini, M., Stemple, D.L., Flicek, P., Houart, C., Bruce, A., Wardle, F.C. (2014) Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC Biology. 12:81
- Miller, A.C., Obholzer, N.D., Shah, A.N., Megason, S.G., and Moens, C.B. (2013) RNA-seq based mapping and candidate identification of mutations from forward genetic screens. Genome research. 23(4):679-686
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Walsh, G.S., Grant, P.K., Morgan, J.A., and Moens, C.B. (2011) Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration. Development (Cambridge, England). 138(14):3033-3042
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Katoh, M., and Katoh, M. (2004) Identification and characterization of human GUKH2 gene in silico. International Journal of Oncology. 24(4):1033-1038
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