ZFIN ID: ZDB-GENE-040824-5
Gene Name: hairy-related 12
Gene Symbol: her12    Nomenclature History

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Previous Name: Hes5c (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Notch signaling pathway; brain development; and somitogenesis. Predicted to localize to nucleus. Is expressed in several structures, including mesoderm; nervous system; neural plate; tail bud; and trunk vasculature. Orthologous to human HES5 (hes family bHLH transcription factor 5).
Genome Resources: Alliance (1),  Gene:402914 (1),  Ensembl(GRCz11):ENSDARG00000032963 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014348Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028498Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24312 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-her12 N/A 1
    MO2-her12 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH her12 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH her12 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Notch signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA her12-201 (1)    Ensembl 1050
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM her12
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tgbac(her12:kaede) her12 Kaede Danio rerio 1 1
    MARKER RELATIONSHIPS
    her12 Contained in: [BAC] CH73-21G5 (1)
    her12 Encodes: [EST] IMAGE:6904047 (1)
    [cDNA] MGC:86804 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_205619 (1) 1037 nt
    Genomic GenBank:CU062502 (1) 62011 nt
    Select Tool
    Polypeptide UniProtKB:Q4QRL6 (1) 155 aa
    Sequence Information (all 13)
    ORTHOLOGY for her12 ( Chr: 23 )
    CITATIONS (53)