ZFIN ID: ZDB-GENE-040824-4
Gene Name: hairy-related 11
Gene Symbol: her11    Nomenclature History

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Previous Name: him (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in midbrain-hindbrain boundary development and negative regulation of neurogenesis. Predicted to localize to nucleus. Is expressed in several structures, including heart; liver; margin; midbrain hindbrain boundary; and midbrain hindbrain boundary neural plate. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human HES7 (hes family bHLH transcription factor 7).
Genome Resources: Alliance (1),  Gene:445409 (1),  Ensembl(GRCz11):ENSDARG00000002707 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 4 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa47 Point Mutation Unknown Unknown ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-her11 N/A 2
MO2-her11 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH her11 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH her11 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process midbrain-hindbrain boundary development (more)
Cellular Component nucleus (more)
Molecular Function protein binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA her11-201 (1)    Ensembl 1166
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM her11 No data available
MARKER RELATIONSHIPS
her11 Contained in: [BAC] CH73-271E23 (1), CH211-153K16 (1)
her11 Encodes: [cDNA] MGC:193985 (1), MGC:193998 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001003886 (1) 1155 nt
Genomic GenBank:BX323810 166625 nt
Select Tool
Polypeptide UniProtKB:Q6W4T8 (1) 274 aa
Sequence Information (all 17)
ORTHOLOGY for her11 ( Chr: 14 )
CITATIONS (27)